PMID- 26283912
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150818
LR  - 20201001
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 9
DP  - 2015
TI  - Diseases associated with leaky hemichannels.
PG  - 267
LID - 10.3389/fncel.2015.00267 [doi]
LID - 267
AB  - Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits 
      called connexins (Cxs) are major pathways for intercellular communication. While 
      HCs connect the intracellular compartment with the extracellular milieu, GJCs 
      allow the interchange of molecules between cytoplasm of two contacting cells. 
      Under physiological conditions, HCs are mostly closed, but they can open under 
      certain stimuli allowing the release of autocrine and paracrine molecules. 
      Moreover, some pathological conditions, like ischemia or other inflammation 
      conditions, significantly increase HCs activity. In addition, some mutations in 
      Cx genes associated with human diseases, such as deafness or cataracts, lead to 
      the formation of more active HCs or "leaky HCs." In this article we will revise 
      cellular and molecular mechanisms underlying the appearance of leaky HCs, and the 
      consequences of their expression in different cellular systems and animal models, 
      in seeking a common pattern or pathological mechanism of disease.
FAU - Retamal, Mauricio A
AU  - Retamal MA
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile.
FAU - Reyes, Edison P
AU  - Reyes EP
AD  - Centro de Fisiologia Celular e Integrativa, Facultad de Medicina, Clinica Alemana 
      Universidad del Desarrollo Santiago, Chile ; Centro de Investigacion Biomedica, 
      Universidad Autonoma de Chile Santiago, Chile.
FAU - Garcia, Isaac E
AU  - Garcia IE
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Instituto de 
      Neurociencia, Facultad de Ciencias, Universidad de Valparaiso Valparaiso, Chile.
FAU - Pinto, Bernardo
AU  - Pinto B
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Instituto de 
      Neurociencia, Facultad de Ciencias, Universidad de Valparaiso Valparaiso, Chile.
FAU - Martinez, Agustin D
AU  - Martinez AD
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Instituto de 
      Neurociencia, Facultad de Ciencias, Universidad de Valparaiso Valparaiso, Chile.
FAU - Gonzalez, Carlos
AU  - Gonzalez C
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Instituto de 
      Neurociencia, Facultad de Ciencias, Universidad de Valparaiso Valparaiso, Chile.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150727
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4515567
OTO - NOTNLM
OT  - cell death
OT  - connexins
OT  - disease
OT  - gap junction channels
OT  - leaky hemichannels
OT  - mutations
EDAT- 2015/08/19 06:00
MHDA- 2015/08/19 06:01
PMCR- 2015/01/01
CRDT- 2015/08/19 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/06/29 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2015/08/19 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2015.00267 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2015 Jul 27;9:267. doi: 10.3389/fncel.2015.00267. 
      eCollection 2015.