PMID- 26284109
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150818
LR  - 20210622
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 6
DP  - 2015
TI  - Hold your horSSEs: controlling structure-selective endonucleases MUS81 and 
      Yen1/GEN1.
PG  - 253
LID - 10.3389/fgene.2015.00253 [doi]
LID - 253
AB  - Repair of DNA lesions through homologous recombination promotes the establishment 
      of stable chromosomal interactions. Multiple helicases, topoisomerases and 
      structure-selective endonucleases (SSEs) act upon recombining joint molecules 
      (JMs) to disengage chromosomal connections and safeguard chromosome segregation. 
      Recent studies on two conserved SSEs - MUS81 and Yen1/GEN1- uncovered multiple 
      layers of regulation that operate to carefully tailor JM-processing according to 
      specific cellular needs. Temporal restriction of SSE function imposes a hierarchy 
      in pathway usage that ensures efficient JM-processing while minimizing reciprocal 
      exchanges between the recombining DNAs. Whereas a conserved strategy of 
      fine-tuning SSE functions exists in different model systems, the precise 
      molecular mechanisms to implement it appear to be significantly different. Here, 
      we summarize the current knowledge on the cellular switches that are in place to 
      control MUS81 and Yen1/GEN1 functions.
FAU - Blanco, Miguel G
AU  - Blanco MG
AD  - Department of Biochemistry and Molecular Biology, Center for Research in 
      Molecular Medicine and Chronic Diseases, University of Santiago de Compostela , 
      Santiago de Compostela, Spain.
FAU - Matos, Joao
AU  - Matos J
AD  - Institute of Biochemistry, Swiss Federal Institute of Technology in Zurich , 
      Zurich, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150730
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC4519697
OTO - NOTNLM
OT  - Cdc14
OT  - Cdc5/PLK1
OT  - Cdk
OT  - DNA repair
OT  - Holliday junction
OT  - nuclease
OT  - recombination
OT  - replication
EDAT- 2015/08/19 06:00
MHDA- 2015/08/19 06:01
PMCR- 2015/07/30
CRDT- 2015/08/19 06:00
PHST- 2015/05/12 00:00 [received]
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2015/08/19 06:01 [medline]
PHST- 2015/07/30 00:00 [pmc-release]
AID - 10.3389/fgene.2015.00253 [doi]
PST - epublish
SO  - Front Genet. 2015 Jul 30;6:253. doi: 10.3389/fgene.2015.00253. eCollection 2015.