PMID- 26284392
OWN - NLM
STAT- MEDLINE
DCOM- 20151124
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 47
IP  - 4
DP  - 2015 Aug 18
TI  - [Efficacy and outcome of palliative TURP in patients with bladder outlet 
      obstruction induced by advanced prostate cancer].
PG  - 597-600
AB  - OBJECTIVE: To evaluate the efficacy and outcome of palliative transurethral 
      resection of the prostate (pTURP) in patients with server bladder outlet 
      obstruction (BOO) due to prostatic obstruction induced by advanced prostate 
      cancer. METHODS: All the 16 patients who had a pTURP between November 2007 and 
      January 2015 due to BOO (high residual urine volume combined with hydronephrosis 
      or urinary retention refractory to medical treatment) at our institution were 
      retrospectively assessed. All the patients were diagnosed with advanced prostate 
      cancer (III stage or IV stage). The clinical data, functional and oncological 
      follow-up results were evaluated. The cancer specific survivals were estimated by 
      Kaplan-Meier analysis. RESULTS: The mean age of the patients was 73.8 years 
      (63-81 years). Five cases were graded in stage III of prostate cancer and 11 in 
      stage IV. The indications for pTURP were refractory urinary retention in 12 
      cases, and high residual urine volume with hydronephrosis in 4 cases. The mean 
      prostate volume at pTURP was 43.2 mL (28-78 mL) and the mean PSA (prostate 
      specific antigen) level before pTURP was 48.2 mug/L (2-107 mug/L). The patients had 
      mean residual urine volume 166.4 mL (50-450 mL) and mean urinary flow rate 3.6 
      mL/s (0-6 mL/s, n=7) before pTURP. It took mean 62.9 min (35-94 min) in pTURP 
      with mean estimated blood loss 126.9 mL (30-263 mL) and mean resected tissue 14.1 
      g (10-22 g). There were no transfusion cases. Postoperative mean serum PSA 20.5 
      mug/L (1-41 mug/L), residual urine volume 43.4 mL (0-400 mL) and urinary flow rate 
      10.1 mL/s (7-16 mL/s, n=7) were shown in these cases. A patient encountered 
      persistent hematuria needing irrigation. Compared with preoperation, the patients 
      had significantly lower serum PSA level (P<0.001), less residual urine volume 
      (P<0.001) and more urinary flow rate (P=0.001) after pTURP. The mean follow-up 
      after pTURP was 36 months (1-86 months). In addition, 2 patients received 
      repeated pTURP. At the time of the latest analysis, 3 patients died from prostate 
      cancer progression. As estimated by Kaplan-Meier analysis, the 2-, 3- and 5-year 
      cancer specific survival rates after pTURP were 91%, 78% and 58%, respectively. 
      CONCLUSION: Despite less resected tissue, greater delay in urination and 
      reoperation rates, pTURP is a fairly effective procedure in patients with server 
      BOO. Although a potential negative impact of pTURP on survival cannot be 
      excluded, the estimated 3- and 5-year cancer specific survival rates in this 
      series seem to justify this intervention.
FAU - Liu, Lei
AU  - Liu L
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, China.
FAU - Hou, Xiao-fei
AU  - Hou XF
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, China.
FAU - Ma, Lu-lin
AU  - Ma LL
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, China.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, China.
FAU - Zhang, Hong-xian
AU  - Zhang HX
AD  - Department of Urology, Peking University Third Hospital, Beijing 100191, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostate-Specific Antigen
MH  - Prostatic Neoplasms/complications/*surgery
MH  - Retrospective Studies
MH  - Survival Rate
MH  - *Transurethral Resection of Prostate
MH  - Urinary Bladder Neck Obstruction/etiology/*surgery
EDAT- 2015/08/19 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2015 Aug 18;47(4):597-600.