PMID- 26284476
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20220321
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 267
IP  - 1
DP  - 2015 Sep
TI  - A bird's eye view of NK cell receptor interactions with their MHC class I 
      ligands.
PG  - 148-66
LID - 10.1111/imr.12319 [doi]
AB  - The surveillance of target cells by natural killer (NK) cells utilizes an 
      ensemble of inhibitory and activating receptors, many of which interact with 
      major histocompatibility complex (MHC) class I molecules. NK cell recognition of 
      MHC class I proteins is important developmentally for the acquisition of full NK 
      cell effector capacity and during target cell recognition, where the engagement 
      of inhibitory receptors and MHC class I molecules attenuates NK cell activation. 
      Human NK cells have evolved two broad strategies for recognition of human 
      leukocyte antigen (HLA) class I molecules: (i) direct recognition of polymorphic 
      classical HLA class I proteins by diverse receptor families such as the killer 
      cell immunoglobulin-like receptors (KIRs), and (ii) indirect recognition of 
      conserved sets of HLA class I-derived peptides displayed on the non-classical 
      HLA-E for recognition by CD94-NKG2 receptors. In this review, we assess the 
      structural basis for the interaction between these NK receptors and their HLA 
      class I ligands and, using the suite of published KIR and CD94-NKG2 ternary 
      complexes, highlight the features that allow NK cells to orchestrate the 
      recognition of a range of different HLA class I proteins.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Saunders, Philippa M
AU  - Saunders PM
AD  - Department of Microbiology and Immunology, The University of Melbourne at the 
      Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
FAU - Vivian, Julian P
AU  - Vivian JP
AD  - Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, 
      Monash University, Clayton, VIC, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, VIC, Australia.
FAU - O'Connor, Geraldine M
AU  - O'Connor GM
AD  - Department of Microbiology and Immunology, The University of Melbourne at the 
      Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
FAU - Sullivan, Lucy C
AU  - Sullivan LC
AD  - Department of Microbiology and Immunology, The University of Melbourne at the 
      Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
FAU - Pymm, Phillip
AU  - Pymm P
AD  - Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, 
      Monash University, Clayton, VIC, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, VIC, Australia.
FAU - Rossjohn, Jamie
AU  - Rossjohn J
AD  - Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, 
      Monash University, Clayton, VIC, Australia.
AD  - ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, 
      Clayton, VIC, Australia.
AD  - Institute of Infection and Immunity, Cardiff University School of Medicine, 
      Cardiff, UK.
FAU - Brooks, Andrew G
AU  - Brooks AG
AD  - Department of Microbiology and Immunology, The University of Melbourne at the 
      Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
LA  - eng
GR  - 12-1076/AICR_/Worldwide Cancer Research/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Natural Killer Cell)
SB  - IM
MH  - Animals
MH  - HLA Antigens/chemistry/*immunology/metabolism
MH  - Histocompatibility Antigens Class I/chemistry/*immunology/metabolism
MH  - Humans
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Ligands
MH  - Models, Molecular
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Receptors, Natural Killer Cell/chemistry/*immunology/metabolism
OTO - NOTNLM
OT  - CD94-NKG2
OT  - human leukocyte antigen
OT  - killer cell immunoglobulin-like receptors
OT  - natural killer cell receptors
EDAT- 2015/08/19 06:00
MHDA- 2016/05/21 06:00
CRDT- 2015/08/19 06:00
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
AID - 10.1111/imr.12319 [doi]
PST - ppublish
SO  - Immunol Rev. 2015 Sep;267(1):148-66. doi: 10.1111/imr.12319.