PMID- 26284481
OWN - NLM
STAT- MEDLINE
DCOM- 20160520
LR  - 20181113
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 267
IP  - 1
DP  - 2015 Sep
TI  - Co-evolution of the MHC class I and KIR gene families in rhesus macaques: 
      ancestry and plasticity.
PG  - 228-45
LID - 10.1111/imr.12313 [doi]
AB  - Researchers dealing with the human leukocyte antigen (HLA) class I and killer 
      immunoglobulin receptor (KIR) multi-gene families in humans are often wary of the 
      complex and seemingly different situation that is encountered regarding these 
      gene families in Old World monkeys. For the sake of comparison, the well-defined 
      and thoroughly studied situation in humans has been taken as a reference. In 
      macaques, both the major histocompatibility complex class I and KIR gene families 
      are plastic entities that have experienced various rounds of expansion, 
      contraction, and subsequent recombination processes. As a consequence, haplotypes 
      in macaques display substantial diversity with regard to gene copy number 
      variation. Additionally, for both multi-gene families, differential levels of 
      polymorphism (allelic variation), and expression are observed as well. A 
      comparative genetic approach has allowed us to answer questions related to 
      ancestry, to shed light on unique adaptations of the species' immune system, and 
      to provide insights into the genetic events and selective pressures that have 
      shaped the range of these gene families.
CI  - (c) 2015 The Authors. Immunological Reviews Published by John Wiley & Sons Ltd.
FAU - de Groot, Natasja G
AU  - de Groot NG
AD  - Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.
FAU - Blokhuis, Jeroen H
AU  - Blokhuis JH
AD  - Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.
FAU - Otting, Nel
AU  - Otting N
AD  - Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.
FAU - Doxiadis, Gaby G M
AU  - Doxiadis GG
AD  - Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.
FAU - Bontrop, Ronald E
AU  - Bontrop RE
AD  - Department of Comparative Genetics & Refinement, BPRC, Rijswijk, The Netherlands.
AD  - Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The 
      Netherlands.
LA  - eng
GR  - 5R24OD011161-13/OD/NIH HHS/United States
GR  - R24 OD011161/OD/NIH HHS/United States
GR  - HHSN272201100013I/AI/NIAID NIH HHS/United States
GR  - HHSN272201100013C/PHS HHS/United States
GR  - HHSN272201100013C/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Animals
MH  - DNA Copy Number Variations/genetics/immunology
MH  - Evolution, Molecular
MH  - Genetic Variation/genetics/*immunology
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Macaca mulatta/genetics/*immunology
MH  - Multigene Family/genetics/immunology
MH  - Receptors, KIR/genetics/*immunology
PMC - PMC4544828
MID - NIHMS688566
OTO - NOTNLM
OT  - KIR
OT  - MHC
OT  - co-evolution
OT  - rhesus macaque
EDAT- 2015/08/19 06:00
MHDA- 2016/05/21 06:00
PMCR- 2015/08/29
CRDT- 2015/08/19 06:00
PHST- 2015/08/19 06:00 [entrez]
PHST- 2015/08/19 06:00 [pubmed]
PHST- 2016/05/21 06:00 [medline]
PHST- 2015/08/29 00:00 [pmc-release]
AID - IMR12313 [pii]
AID - 10.1111/imr.12313 [doi]
PST - ppublish
SO  - Immunol Rev. 2015 Sep;267(1):228-45. doi: 10.1111/imr.12313.