PMID- 26286041
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20181202
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 15
DP  - 2015 Aug 19
TI  - Effects of Kaixinjieyu, a Chinese herbal medicine preparation, on neurovascular 
      unit dysfunction in rats with vascular depression.
PG  - 291
LID - 10.1186/s12906-015-0808-z [doi]
LID - 291
AB  - BACKGROUND: Kaixinjieyu (KJ), derived from Kaixin and Sini powder, is an 
      effective Chinese herbal medicine preparation used in the treatment of vascular 
      depression (VD). We hypothesize that broad antidepressant effect of KJ results 
      from the improved neurovascular unit (NVU) function via neurogenesis, 
      permeability of blood-brain barrier (BBB) and balance of the fibrinolytic system. 
      METHODS: A VD model of rat was established by chronic unpredictable mild stress 
      and separation after ligation of the bilateral common carotid arteries. The rats 
      were treated with KJ and fluoxetine hydrochloride (FLU) for 21 days, 
      respectively. The behavior and cerebral perfusion were investigated and then NVU 
      functions including neurogenesis, permeability of BBB and balance of the 
      fibrinolytic system were studied using a number of biomarkers and TUNEL assay. 
      RESULTS: KJ significantly increased sucrose preference, moving distance, number 
      of rearing and cortical blood flow. NVU functions measured by brain-derived 
      neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) and tissue 
      plasminogen activator (t-PA) proteins and mRNA, zona occludens protein-1 (ZO-1), 
      occludin and claudin-5 proteins increased significantly, whereas, plasminogen 
      activator inhibitor-1 (PAI-1), matrix metalloproteinase-2 (MMP-2) proteins, mRNA 
      and apoptotic rates of neurons decreased significantly with treatment of KJ. FLU 
      has a function similar to KJ in behavior, regulation of BDNF, TrkB, MMP-2, 
      occludin and apoptotic rates of cells. CONCLUSIONS: KJ has function of reducing 
      depression-like behavior and improving cerebral hypoperfusion, which might be 
      mediated by the up-regulation of neurogenesis and tight junction of BBB, and 
      balance of the fibrinolytic system. The results imply that KJ is better than FLU 
      in improving cerebral hypoperfusion and the fibrinolytic system.
FAU - Pan, Juhua
AU  - Pan J
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. panjuhua@126.com.
FAU - Lei, Xiaoming
AU  - Lei X
AD  - Huangpi District Hospital of Traditional Chinese Medicine, Wuhan, Hubei, 430300, 
      China. leixiaoming66@126.com.
FAU - Wang, Jialong
AU  - Wang J
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. footprint666@163.com.
FAU - Huang, Shijing
AU  - Huang S
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. gamhsj@126.com.
FAU - Wang, Yanyun
AU  - Wang Y
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. gamwyy@126.com.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. zhangying1179@163.com.
FAU - Chen, Wen
AU  - Chen W
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. gamwendy@163.com.
FAU - Li, Duojiao
AU  - Li D
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. gam_lee@126.com.
FAU - Zheng, Jun
AU  - Zheng J
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. zhengjun_321@126.com.
FAU - Cui, Hanming
AU  - Cui H
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. cui-yaoshi@163.com.
FAU - Liu, Qihua
AU  - Liu Q
AD  - Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, 
      China. gam-yaoyan@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150819
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (kaixin jieyu)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*drug effects
MH  - *Cardiovascular Diseases
MH  - *Depression
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Neurogenesis/*drug effects
MH  - Neurovascular Coupling/drug effects
MH  - Rats
PMC - PMC4545710
EDAT- 2015/08/20 06:00
MHDA- 2016/02/19 06:00
PMCR- 2015/08/19
CRDT- 2015/08/20 06:00
PHST- 2015/02/16 00:00 [received]
PHST- 2015/08/07 00:00 [accepted]
PHST- 2015/08/20 06:00 [entrez]
PHST- 2015/08/20 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
PHST- 2015/08/19 00:00 [pmc-release]
AID - 10.1186/s12906-015-0808-z [pii]
AID - 808 [pii]
AID - 10.1186/s12906-015-0808-z [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2015 Aug 19;15:291. doi: 10.1186/s12906-015-0808-z.