PMID- 26286637
OWN - NLM
STAT- MEDLINE
DCOM- 20151217
LR  - 20150922
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 75
IP  - 15
DP  - 2015 Nov
TI  - Perineural invasion in prostate biopsy specimens is associated with increased 
      bone metastasis in prostate cancer.
PG  - 1783-9
LID - 10.1002/pros.23067 [doi]
AB  - BACKGROUND: We aimed to evaluate the relationship between perineural invasion 
      (PNI) and bone metastasis in prostate cancer (PCa). METHODS: We retrospectively 
      reviewed the data of 633 PCas who had whole-body bone scan (WBBS) between 2008 
      and 2014. We recorded the age, clinical T-stage, total PSA (tPSA) prior to 
      biopsy, Gleason sum (GS), and PNI in transrectal ultrasound guided biopsy 
      (TRUS-Bx) and digital rectal examination findings. Bone metastases were assessed 
      with WBBS and magnetic resonance image if WBBS was suspicious. We divided the 
      patients into two groups according to NCCN criteria: (Group 1) bone scan not 
      indicated, (Group 2) bone scan indicated. RESULTS: There were 262 patients in 
      Group 1 and 371 in 2. There is not significant relationship between PNI and bone 
      metastasis in Group 1. However, there is very limited number of metastatic 
      patients (n = 12) in this group. There is a strong relationship between PNI and 
      bone metastasis in Group 2 (P = 0.001). Sensitivity, specificity and positive 
      predictive value of PNI for bone metastasis were 72.4%, 81.7%, and 77.7%, 
      respectively. In this group, tPSA, GS, positive DRE, and PNI were significant 
      covariates for prediction of bone metastasis in univariate and multivariate 
      analysis (except age). The most powerful predictor was PNI, and it increased the 
      risk of bone metastasis 11-fold. CONCLUSIONS: PNI in the TRUS-Bx specimens is the 
      most powerful predictive histopathological feature for bone metastasis, by 
      increasing the risk of bone metastasis 11-fold in NCCN bone scan indicated 
      patients (Group 2).
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Ciftci, Seyfettin
AU  - Ciftci S
AD  - Department of Urology, Sivas Numune State Hospital, Sivas, Turkey.
FAU - Yilmaz, Hasan
AU  - Yilmaz H
AD  - Department of Urology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
FAU - Ciftci, Esra
AU  - Ciftci E
AD  - Department of Nuclear Medicine, Sivas Cumhuriyet University Medical Faculty, 
      Sivas, Turkey.
FAU - Simsek, Emrah
AU  - Simsek E
AD  - Department of Urology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
FAU - Ustuner, Murat
AU  - Ustuner M
AD  - Department of Urology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
FAU - Yavuz, Ufuk
AU  - Yavuz U
AD  - Department of Urology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
FAU - Muezzinoglu, Bahar
AU  - Muezzinoglu B
AD  - Department of Pathology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
FAU - Dillioglugil, Ozdal
AU  - Dillioglugil O
AD  - Department of Urology, University of Kocaeli Medical Faculty, Kocaeli, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20150819
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Bone Neoplasms/*secondary
MH  - Digital Rectal Examination
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Invasiveness/*pathology
MH  - Prostate/*pathology
MH  - Prostatic Neoplasms/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - bone metastasis
OT  - perineural invasion
OT  - prostate biopsy
OT  - prostate cancer
EDAT- 2015/08/20 06:00
MHDA- 2015/12/19 06:00
CRDT- 2015/08/20 06:00
PHST- 2015/06/25 00:00 [received]
PHST- 2015/08/06 00:00 [accepted]
PHST- 2015/08/20 06:00 [entrez]
PHST- 2015/08/20 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
AID - 10.1002/pros.23067 [doi]
PST - ppublish
SO  - Prostate. 2015 Nov;75(15):1783-9. doi: 10.1002/pros.23067. Epub 2015 Aug 19.