PMID- 26287344
OWN - NLM
STAT- MEDLINE
DCOM- 20160107
LR  - 20150820
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 17
IP  - 8
DP  - 2015 Aug
TI  - [Association between ZNF365 gene polymorphisms and bronchial asthma in children].
PG  - 811-4
AB  - OBJECTIVE: To study the association of single nucleotide polymorphisms (SNP) 
      (rs2393903 and rs10995251) in ZNF365 gene with bronchial asthma and its clinical 
      characteristics in Han Chinese children in Hubei, China. METHODS: A total of 221 
      children with bronchial asthma and 243 normal children, all of whom were from 
      Hubei, were recruited to carry out a case-control study. The genotype and allele 
      frequencies of two SNPs in ZNF365 gene were determined using the polymerase chain 
      reaction-restriction fragment length polymorphism technique. RESULTS: There were 
      no significant differences in the distribution of three genotypes (GG, GA, AA) 
      and allele frequency in SNP rs2393903 between the asthma and control groups 
      (P>0.05). However, there were significant differences in the distribution of 
      three genotypes (CC, CT, TT) and allele frequency in SNP rs10995251 between the 
      asthma and control groups (P<0.05); C allele was a risk factor (OR=1.380). The 
      asthmatic children with CC genotype of SNP rs10995251 had a significantly higher 
      serum level of total immunoglobulin E (IgE) than those with TT genotype (P<0.05). 
      CONCLUSIONS: The SNP rs10995251 in ZNF365 gene is associated with the 
      susceptibility to bronchial asthma in children in Hubei, China, and the SNP may 
      affect the level of serum IgE in these children.
FAU - Huang, Juan
AU  - Huang J
AD  - Department of Pediatrics, Xianning Central Hospital, Xianning, Hubei 437100, 
      China. hbzhaohl@sina.com.
FAU - Zhao, Hong-Ling
AU  - Zhao HL
FAU - Cheng, Yan-Yang
AU  - Cheng YY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (ZNF365 protein, human)
SB  - IM
MH  - Asthma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Transcription Factors/*genetics
EDAT- 2015/08/20 06:00
MHDA- 2016/01/08 06:00
CRDT- 2015/08/20 06:00
PHST- 2015/08/20 06:00 [entrez]
PHST- 2015/08/20 06:00 [pubmed]
PHST- 2016/01/08 06:00 [medline]
AID - 10.7499/j.issn.1008-8830.2015.08.010 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2015 Aug;17(8):811-4.