PMID- 26287376
OWN - NLM
STAT- MEDLINE
DCOM- 20160510
LR  - 20231111
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 8
DP  - 2015
TI  - Race, Ethnicity and Ancestry in Unrelated Transplant Matching for the National 
      Marrow Donor Program: A Comparison of Multiple Forms of Self-Identification with 
      Genetics.
PG  - e0135960
LID - 10.1371/journal.pone.0135960 [doi]
LID - e0135960
AB  - We conducted a nationwide study comparing self-identification to genetic ancestry 
      classifications in a large cohort (n = 1752) from the National Marrow Donor 
      Program. We sought to determine how various measures of self-identification 
      intersect with genetic ancestry, with the aim of improving matching algorithms 
      for unrelated bone marrow transplant. Multiple dimensions of self-identification, 
      including race/ethnicity and geographic ancestry were compared to classifications 
      based on ancestry informative markers (AIMs), and the human leukocyte antigen 
      (HLA) genes, which are required for transplant matching. Nearly 20% of responses 
      were inconsistent between reporting race/ethnicity versus geographic ancestry. 
      Despite strong concordance between AIMs and HLA, no measure of 
      self-identification shows complete correspondence with genetic ancestry. In 
      certain cases geographic ancestry reporting matches genetic ancestry not 
      reflected in race/ethnicity identification, but in other cases geographic 
      ancestries show little correspondence to genetic measures, with important 
      differences by gender. However, when respondents assign ancestry to grandparents, 
      we observe sub-groups of individuals with well- defined genetic ancestries, 
      including important differences in HLA frequencies, with implications for 
      transplant matching. While we advocate for tailored questioning to improve 
      accuracy of ancestry ascertainment, collection of donor grandparents' information 
      will improve the chances of finding matches for many patients, particularly for 
      mixed-ancestry individuals.
FAU - Hollenbach, Jill A
AU  - Hollenbach JA
AD  - Department of Neurology, University of California, San Francisco School of 
      Medicine, San Francisco, California, United States of America.
FAU - Saperstein, Aliya
AU  - Saperstein A
AD  - Department of Sociology, Stanford University, Stanford, California, United States 
      of America.
FAU - Albrecht, Mark
AU  - Albrecht M
AD  - Bioinformatics Research, National Marrow Donor Program, Minneapolis, Minnesota, 
      United States of America.
FAU - Vierra-Green, Cynthia
AU  - Vierra-Green C
AD  - Center for International Blood and Marrow Transplant Research, Minneapolis, 
      Minnesota, United States of America.
FAU - Parham, Peter
AU  - Parham P
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, California, United States of America; Department of Microbiology & 
      Immunology, Stanford University School of Medicine, Stanford, California, United 
      States of America.
FAU - Norman, Paul J
AU  - Norman PJ
AD  - Department of Structural Biology, Stanford University School of Medicine, 
      Stanford, California, United States of America; Department of Microbiology & 
      Immunology, Stanford University School of Medicine, Stanford, California, United 
      States of America.
FAU - Maiers, Martin
AU  - Maiers M
AD  - Bioinformatics Research, National Marrow Donor Program, Minneapolis, Minnesota, 
      United States of America.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150819
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Bone Marrow
MH  - Bone Marrow Transplantation/methods
MH  - Ethnicity/*genetics
MH  - Female
MH  - Genetics, Medical/methods
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Male
MH  - Racial Groups/*genetics
MH  - Tissue Donors
MH  - Transplant Recipients
PMC - PMC4545604
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/08/20 06:00
MHDA- 2016/05/11 06:00
PMCR- 2015/08/19
CRDT- 2015/08/20 06:00
PHST- 2015/03/01 00:00 [received]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/08/20 06:00 [entrez]
PHST- 2015/08/20 06:00 [pubmed]
PHST- 2016/05/11 06:00 [medline]
PHST- 2015/08/19 00:00 [pmc-release]
AID - PONE-D-15-09043 [pii]
AID - 10.1371/journal.pone.0135960 [doi]
PST - epublish
SO  - PLoS One. 2015 Aug 19;10(8):e0135960. doi: 10.1371/journal.pone.0135960. 
      eCollection 2015.