PMID- 26287940
OWN - NLM
STAT- MEDLINE
DCOM- 20160711
LR  - 20221207
IS  - 1744-6880 (Electronic)
IS  - 1744-6872 (Linking)
VI  - 25
IP  - 11
DP  - 2015 Nov
TI  - Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma 
      susceptibility in an Eastern Chinese population.
PG  - 521-30
LID - 10.1097/FPC.0000000000000163 [doi]
AB  - BACKGROUND AND AIM: Genetic variants in the mammalian target of rapamycin (mTOR) 
      gene have become an interesting topic for the study of genetic susceptibility to 
      cancer, but their associations with the risk of gastric cancer have not been 
      fully investigated. MATERIALS AND METHODS: In a hospital-based case-control study 
      of 1002 gastric cancer patients and 1003 cancer-free controls, we genotyped four 
      potentially functional single nucleotide polymorphisms (SNPs) (rs1034528G>C, 
      rs17036508T>C, rs3806317A>G, and rs2295080T>G) of mTOR and assessed their 
      associations with the risk of gastric cancer using univariate and multivariate 
      logistic regression analyses. We also used the multifactorial dimension reduction 
      analysis to explore possible interactions and the false-positive report 
      probabilities to assess significant findings. RESULTS: We found that rs1034528 
      CG/CC and rs3806317 GA/GG variant genotypes were associated with an increased 
      risk of gastric cancer under a dominant model (adjusted odds ratio=1.27 and 1.22, 
      respectively). In the combined analysis of all four SNPs under investigation, 
      patients with 3-4 risk genotypes of mTOR had a significantly increased risk of 
      gastric cancer (adjusted odds ratio=1.46, 95% confidence interval=1.19-1.79) 
      compared with those with 0-2 risk genotypes. Stratified analysis indicated that 
      this risk was more pronounced in subgroups of men, never-smokers, never-drinkers, 
      and clinical stages III+IV. The multifactorial dimension reduction analysis 
      suggested some evidence of interactions between the combined genotypes and other 
      risk factors for gastric cancer. CONCLUSION: These findings suggest that 
      potentially functional SNPs of mTOR may individually or collectively contribute 
      to the risk of gastric cancer. Larger studies with diverse ethnic populations are 
      warranted to validate our findings.
FAU - Wang, Meng-Yun
AU  - Wang MY
AD  - aCancer Institute, Collaborative Innovation Center for Cancer Medicine 
      bDepartment of Medical Oncology cDepartment of Abdominal Surgery dDepartment of 
      Pathology, Fudan University Shanghai Cancer Center eDepartment of Oncology, 
      Shanghai Medical College fMinistry of Education Key Laboratory of Contemporary 
      Anthropology, State Key Laboratory of Genetic Engineering, School of Life 
      Sciences, Fudan University, Shanghai gState Key Laboratory of Oncology in South 
      China, Department of Experimental Research, Collaborative Innovation Center for 
      Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangdong hFudan-Taizhou 
      Institute of Health Sciences, Taizhou, Jiangsu, China iDuke Cancer Institute, 
      Duke University Medical Center, Durham, North Carolina, USA.
FAU - Li, Qiao-Xin
AU  - Li QX
FAU - He, Jing
AU  - He J
FAU - Qiu, Li-Xin
AU  - Qiu LX
FAU - Wang, Ya-Nong
AU  - Wang YN
FAU - Li, Jin
AU  - Li J
FAU - Sun, Meng-Hong
AU  - Sun MH
FAU - Wang, Xiao-Feng
AU  - Wang XF
FAU - Yang, Ya-Jun
AU  - Yang YJ
FAU - Wang, Jiu-Cun
AU  - Wang JC
FAU - Jin, Li
AU  - Jin L
FAU - Wei, Qing-Yi
AU  - Wei QY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacogenet Genomics
JT  - Pharmacogenetics and genomics
JID - 101231005
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adenocarcinoma/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Cell Line
MH  - China
MH  - Female
MH  - Gene Expression
MH  - Genes, Dominant
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - RNA, Messenger/genetics
MH  - Risk Factors
MH  - Stomach Neoplasms/*genetics
MH  - TOR Serine-Threonine Kinases/*genetics
EDAT- 2015/08/20 06:00
MHDA- 2016/07/12 06:00
CRDT- 2015/08/20 06:00
PHST- 2015/08/20 06:00 [entrez]
PHST- 2015/08/20 06:00 [pubmed]
PHST- 2016/07/12 06:00 [medline]
AID - 10.1097/FPC.0000000000000163 [doi]
PST - ppublish
SO  - Pharmacogenet Genomics. 2015 Nov;25(11):521-30. doi: 
      10.1097/FPC.0000000000000163.