PMID- 26289328
OWN - NLM
STAT- MEDLINE
DCOM- 20160725
LR  - 20181202
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 22
IP  - 24
DP  - 2015 Dec
TI  - Blood concentrations and risk assessment of persistent organochlorine compounds 
      in newborn boys in Turkey. A pilot study.
PG  - 19896-904
LID - 10.1007/s11356-015-5179-y [doi]
AB  - Even early life in utero cannot provide a safe place for newborns. The first 
      acquaintance with chemicals takes place in utero and/or with mother's milk after 
      delivery. Besides legislations and bans to persistent organic pollutants (POPs), 
      these chemicals are still affecting the general population especially the 
      children as they are one of the populations most susceptible to chemicals, and 
      also the health problems may arise in the future. Our objective is to collect the 
      first data in newborns in Turkey to determine baseline levels of POPs in the 
      general population and estimate the potential cancer risk related to exposure. 
      Twenty-nine organochlorine pesticides (OCPs) and 18 polychlorinated biphenyl 
      (PCB) congeners in blood samples of newborn boys (0-1 month old) who were born in 
      Istanbul, Turkey, in 2010-2012 were evaluated with high-resolution gas 
      chromatography-high-resolution mass spectrometry (HRGC/HRMS). Results for 
      analyzed chlorinated compounds are as follows: hexachlorocyclohexane (SigmaHCH) 
      1828 +/- 3650 pg/g lipid, dichlorodiphenyltrichloroethane (SigmaDDT) 10,000 +/- 15,398 
      pg/g lipid, and SigmaPCB 1068 +/- 1823 pg/g lipid. 4,4'-DDT, 
      4,4'-dichlorodiphenyldichloroethylene (4,4'-DDE), hexachlorobenzene, and PCB 138 
      and 153 are the major contaminants. New POPs as lindane 61 +/- 268 pg/g lipid, 
      pentachlorobenzene 13 +/- 74 pg/g lipid, and endosulfan 29 +/- 106 pg/g lipid are 
      also detected in blood. Estimated total risk for lifetime PCB exposure is less 
      than 1 x 10(-5), an acceptable risk. Blood concentration levels will be important 
      base data in the assessment of health concerns of newborns as well as for studies 
      about how endocrine disruptors affect humans.
FAU - Ulutas, Onur Kenan
AU  - Ulutas OK
AD  - Department of Toxicology, Faculty of Pharmacy, Gazi University, Yenimahalle, 
      06330, Ankara, Turkey. onurkenan@gmail.com.
FAU - Cok, Ismet
AU  - Cok I
AD  - Department of Toxicology, Faculty of Pharmacy, Gazi University, Yenimahalle, 
      06330, Ankara, Turkey.
FAU - Darendeliler, Feyza
AU  - Darendeliler F
AD  - Department of Pediatrics, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Aydin, Banu
AU  - Aydin B
AD  - Department of Pediatrics, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Coban, Asuman
AU  - Coban A
AD  - Department of Pediatrics, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Henkelmann, Bernhard
AU  - Henkelmann B
AD  - Molecular Exposomics, Helmholtz Zentrum Munchen - Deutsches Forschungszentrum fur 
      Gesundheit und Umwelt, Ingolstadter Landstr 1, 85764, Neuherberg, Germany.
FAU - Schramm, Karl-Werner
AU  - Schramm KW
AD  - Molecular Exposomics, Helmholtz Zentrum Munchen - Deutsches Forschungszentrum fur 
      Gesundheit und Umwelt, Ingolstadter Landstr 1, 85764, Neuherberg, Germany.
AD  - Wissenschaftszentrum Weihenstephan fur Ernahrung, Landnutzung und Umwelt, 
      Department fur Biowissenschaften, Technische Universitat Munchen, Weihenstephaner 
      Steig 23, 85350, Freising, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150821
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Endocrine Disruptors/blood
MH  - Environmental Exposure/*analysis
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Infant, Newborn
MH  - Male
MH  - Milk, Human/chemistry
MH  - Pilot Projects
MH  - Risk Assessment
MH  - Turkey
OTO - NOTNLM
OT  - Blood
OT  - Boy
OT  - Newborn
OT  - OCP
OT  - PCB
OT  - Turkey
EDAT- 2015/08/21 06:00
MHDA- 2016/07/28 06:00
CRDT- 2015/08/21 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/08/07 00:00 [accepted]
PHST- 2015/08/21 06:00 [entrez]
PHST- 2015/08/21 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
AID - 10.1007/s11356-015-5179-y [pii]
AID - 10.1007/s11356-015-5179-y [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2015 Dec;22(24):19896-904. doi: 
      10.1007/s11356-015-5179-y. Epub 2015 Aug 21.