PMID- 26291892
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20181113
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 78
IP  - 17
DP  - 2015
TI  - Investigations into the Immunotoxicity and Allergic Potential Induced by Topical 
      Application of N-Butylbenzenesulfonamide (NBBS) in a Murine Model.
PG  - 1122-32
LID - 10.1080/15287394.2015.1056898 [doi]
AB  - N-Butylbenzene sulfonamide (NBBS) is a commonly used plasticizer found in 
      numerous products. Due to its extensive use, lack of adequate toxicological data, 
      and suspicion of toxicity based on the presence of structural alerts, it was 
      nominated to the National Toxicology Program for comprehensive toxicological 
      testing. The purpose of this study was to evaluate the potential for 
      hypersensitivity and immune suppression following dermal exposure to NBBS using a 
      murine model. NBBS tested negative in a combined irritancy/local lymph node assay 
      (LLNA), classifying it as nonirritating and nonsensitizing. To estimate the 
      immunosuppressive potential of NBBS, assays that assessed immunotoxicity were 
      performed, including the immumnoglobulin (Ig) M response to T-cell-dependent 
      antigen sheep red blood cells (SRBC), using the plaque-forming cell (PFC) assay 
      and immune cell phenotyping. After a 28-d treatment with NBBS, mice exposed to 
      the lowest concentration (25% NBBS) showed a significant increase in 
      IgM-producing B cells in the spleen. No marked changes were identified in immune 
      cell markers in the lymph node. In contrast to body weight, a significant 
      elevation in kidney and liver weight was observed following dermal exposure to 
      all concentrations of NBBS. These results demonstrate that dermal exposure to 
      NBBS, other than liver and kidney toxicity, did not apparently induce 
      immunotoxicity in a murine model.
FAU - Marrocco, Antonella
AU  - Marrocco A
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
FAU - Meade, B Jean
AU  - Meade BJ
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
FAU - Long, Carrie M
AU  - Long CM
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
FAU - Lukomska, Ewa
AU  - Lukomska E
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
FAU - Marshall, Nikki B
AU  - Marshall NB
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
FAU - Anderson, Stacey E
AU  - Anderson SE
AD  - a National Institute for Occupational Safety and Health , Morgantown , West 
      Virginia , USA.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Journal Article
DEP - 20150820
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Plasticizers)
RN  - 0 (Sulfonamides)
RN  - YO7UAW6717 (N-butylbenzenesulfonamide)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Female
MH  - Immunoglobulin G/immunology
MH  - Immunosuppressive Agents/pharmacology
MH  - Lymph Nodes/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plasticizers/*toxicity
MH  - Sheep
MH  - Spleen/drug effects/immunology
MH  - Sulfonamides/*toxicity
MH  - T-Lymphocytes/drug effects/immunology
MH  - Toxicity Tests
PMC - PMC4605868
MID - NIHMS718276
OID - NLM: HHSPA718276
COIS- The authors declare no conflicts of interest.
EDAT- 2015/08/21 06:00
MHDA- 2016/01/14 06:00
PMCR- 2015/10/14
CRDT- 2015/08/21 06:00
PHST- 2015/08/21 06:00 [entrez]
PHST- 2015/08/21 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
PHST- 2015/10/14 00:00 [pmc-release]
AID - 10.1080/15287394.2015.1056898 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2015;78(17):1122-32. doi: 
      10.1080/15287394.2015.1056898. Epub 2015 Aug 20.