PMID- 26292404
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 33
IP  - 4
DP  - 2015 Apr
TI  - [Multiresidue analysis of 63 veterinary drugs in meat by dispersive solid-phase 
      extraction and high performance liquid chromatography-tandem mass spectrometry].
PG  - 354-62
AB  - A novel multiresidue analytical method has been developed and validated for the 
      determination of five classes of veterinary drugs including 18 beta-lactams, 15 
      quinolones, 21 sulfonamides, 3 sulfonamide potentiators and 6 antiparasitics in 
      meat using dispersive solid-phase extraction (dispersive-SPE) and high 
      performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The 
      analytes were extracted with a vortex mixer by 0.1 mol/L Na2 EDTA solution and 
      acetonitrile containing 1% (v/v) acetic acid, and then the extracts were purified 
      using dispersive-SPE with C18 sorbent. Electrospray ionization mass spectrometry 
      was operated in positive mode using dynamic multiple reaction monitoring (DMRM) 
      for the qualitative and quantitative analysis of the 63 analytes after the 
      separation on a Poroshell EC-C18 column (100 mm x 2.1 mm, 2.4 microm). The 
      correlation coefficients of linear calibration curves were over 0.99 in the 
      corresponding concentration ranges. The average recoveries of the 63 analytes 
      ranged from 62.2% to 112.0%, and the relative standard deviations (RSDs) were 
      3.1%-16.3% in spiked meat (pork, beef and chicken muscle) at three levels. The 
      limits of detection (LODs, S/N >/= 3) and the limits of quantification (LOQs, S/N >/= 
      10) were 0.1-3.0 microg/kg and 0.5-10.0 microg/kg, respectively. The method is simple, 
      rapid, sensitive, reliable and suitable for the determination of residues in 
      animal products.
FAU - Luo, Huitai
AU  - Luo H
FAU - Xie, Mengting
AU  - Xie M
FAU - Huang, Xiaolan
AU  - Huang X
FAU - Wu, Huiqin
AU  - Wu H
FAU - Zhu, Zhixin
AU  - Zhu Z
FAU - Huang, Fang
AU  - Huang F
FAU - Lin, Xiaoshan
AU  - Lin X
FAU - Ouyang, Gangfeng
AU  - Ouyang G
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Chickens
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Food Contamination/*analysis
MH  - Meat/*analysis
MH  - Solid Phase Extraction
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Swine
MH  - Tandem Mass Spectrometry
MH  - Veterinary Drugs/*analysis
EDAT- 2015/08/22 06:00
MHDA- 2015/09/09 06:00
CRDT- 2015/08/22 06:00
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
AID - 10.3724/sp.j.1123.2014.12005 [doi]
PST - ppublish
SO  - Se Pu. 2015 Apr;33(4):354-62. doi: 10.3724/sp.j.1123.2014.12005.