PMID- 26294136
OWN - NLM
STAT- MEDLINE
DCOM- 20160711
LR  - 20150909
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 60
IP  - 5
DP  - 2015 Sep
TI  - The Effects of Dextromethorphan on Driving Performance and the Standardized Field 
      Sobriety Test.
PG  - 1258-62
LID - 10.1111/1556-4029.12833 [doi]
AB  - Dextromethorphan (DXM) is abused most commonly among adolescents as a 
      recreational drug to generate a dissociative experience. The objective of the 
      study was to assess driving with and without DXM ingestion. The effects of 
      one-time maximum daily doses of DXM 120 mg versus a guaifenesin 400 mg dose were 
      compared among 40 healthy subjects using a crossover design. Subjects' ability to 
      drive was assessed by their performance in a driving simulator (STISIM(R) Drive 
      driving simulator software) and by conducting a standardized field sobriety test 
      (SFST) administered 1-h postdrug administration. The one-time dose of DXM 120 mg 
      did not demonstrate driving impairment on the STISIM(R) Drive driving simulator or 
      increase SFST failures compared to guaifenesin 400 mg. Doses greater than the 
      currently recommended maximum daily dose of 120 mg are necessary to perturb 
      driving behavior.
CI  - (c) 2015 American Academy of Forensic Sciences.
FAU - Perry, Paul J
AU  - Perry PJ
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Fredriksen, Kristian
AU  - Fredriksen K
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Chew, Stephanie
AU  - Chew S
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Ip, Eric J
AU  - Ip EJ
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Lopes, Ingrid
AU  - Lopes I
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Doroudgar, Shadi
AU  - Doroudgar S
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
FAU - Thomas, Kelan
AU  - Thomas K
AD  - Touro University California College of Pharmacy, Vallejo, CA, 94592.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150821
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Antitussive Agents)
RN  - 0 (Expectorants)
RN  - 0 (Nonprescription Drugs)
RN  - 495W7451VQ (Guaifenesin)
RN  - 7355X3ROTS (Dextromethorphan)
SB  - IM
MH  - Adult
MH  - Antitussive Agents/administration & dosage/*adverse effects
MH  - Automobile Driving
MH  - Computer Simulation
MH  - Cross-Over Studies
MH  - Dextromethorphan/administration & dosage/*adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - *Driving Under the Influence
MH  - Expectorants/administration & dosage/adverse effects
MH  - Female
MH  - Guaifenesin/administration & dosage/adverse effects
MH  - Humans
MH  - Male
MH  - Nonprescription Drugs
MH  - *Substance Abuse Detection
OTO - NOTNLM
OT  - antitussive
OT  - cough suppressant
OT  - dextromethorphan
OT  - driving performance
OT  - driving simulator
OT  - forensic science
OT  - over-the-counter medications
OT  - standardized field sobriety test
EDAT- 2015/08/22 06:00
MHDA- 2016/07/12 06:00
CRDT- 2015/08/22 06:00
PHST- 2014/06/17 00:00 [received]
PHST- 2014/09/22 00:00 [revised]
PHST- 2014/10/06 00:00 [accepted]
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2016/07/12 06:00 [medline]
AID - 10.1111/1556-4029.12833 [doi]
PST - ppublish
SO  - J Forensic Sci. 2015 Sep;60(5):1258-62. doi: 10.1111/1556-4029.12833. Epub 2015 
      Aug 21.