PMID- 26294221
OWN - NLM
STAT- MEDLINE
DCOM- 20160819
LR  - 20181202
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 273
IP  - 1
DP  - 2016 Jan
TI  - Open partial horizontal laryngectomy for salvage after failure of CO(2) 
      laser-assisted surgery for glottic carcinoma.
PG  - 169-75
LID - 10.1007/s00405-015-3734-2 [doi]
AB  - Total laryngectomy (TL) is often still recommended as a salvage approach for 
      recurrent laryngeal squamous cell carcinoma (LSCC). Considering LSCC recurrences 
      after the failure of primary transoral laser microsurgery (TLM), open partial 
      horizontal laryngectomy (OPHL) could be a valid alternative to TL in selected 
      patients. The aim of the present study was to analyze retrospectively the 
      oncological outcome of a consecutive series of 17 patients treated at the 
      Otolaryngology Unit of Vittorio Veneto Hospital (Italy) with OPHL after primary 
      TLM had failed. Nine patients (53 %) had no further recurrences after salvage 
      OPHL. Eight patients had a second recurrence of LSCC after OPHL, and five of them 
      were cured by further salvage treatment, while the other three died of their 
      disease. We found an overall and disease-specific survival both of 82 % and a 
      loco-regional control rate and an ultimate organ preservation rate of 82 and 70 
      %, respectively. Patients who underwent two-stage bilateral cordectomy for 
      primary glottic carcinoma showed a trend towards a higher rate of second 
      recurrences, a lower ultimate organ preservation rate and a shorter disease-free 
      survival after salvage OPHL. Further studies on larger cohorts of patients are 
      needed to identify potential clinical and/or pathological prognostic parameters 
      capable of pinpointing patients at higher risk of second recurrences after 
      salvage OPHL in cases where TLM has failed. A salvage TL might be reasonably 
      proposed as a first salvage choice in such cases.
FAU - Lucioni, Marco
AU  - Lucioni M
AD  - Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
FAU - Bertolin, Andy
AU  - Bertolin A
AD  - Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
FAU - Lionello, Marco
AU  - Lionello M
AD  - Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy. 
      marcolionello@email.it.
AD  - Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 
      Via Giustiniani 2, 35128, Padova, Italy. marcolionello@email.it.
FAU - Giacomelli, Luciano
AU  - Giacomelli L
AD  - Department of Medicine DIMED, University of Padova, Padova, Italy.
FAU - Rizzotto, Giuseppe
AU  - Rizzotto G
AD  - Otolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
FAU - Marioni, Gino
AU  - Marioni G
AD  - Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 
      Via Giustiniani 2, 35128, Padova, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150821
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Aged
MH  - *Carcinoma, Squamous Cell/epidemiology/pathology/surgery
MH  - Disease-Free Survival
MH  - Female
MH  - *Glottis/pathology/surgery
MH  - Humans
MH  - Italy/epidemiology
MH  - Laryngeal Neoplasms/epidemiology/pathology/surgery
MH  - Laryngectomy/*methods
MH  - *Laser Therapy/adverse effects/instrumentation/methods
MH  - Lasers, Gas
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local/pathology/surgery
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Reoperation/methods/statistics & numerical data
MH  - Retrospective Studies
MH  - Salvage Therapy/*methods
OTO - NOTNLM
OT  - Glottic carcinoma
OT  - Laser
OT  - Partial laryngectomy
OT  - Prognosis
OT  - Salvage
EDAT- 2015/08/22 06:00
MHDA- 2016/08/20 06:00
CRDT- 2015/08/22 06:00
PHST- 2015/05/06 00:00 [received]
PHST- 2015/07/21 00:00 [accepted]
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2016/08/20 06:00 [medline]
AID - 10.1007/s00405-015-3734-2 [pii]
AID - 10.1007/s00405-015-3734-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2016 Jan;273(1):169-75. doi: 
      10.1007/s00405-015-3734-2. Epub 2015 Aug 21.