PMID- 26294793
OWN - NLM
STAT- MEDLINE
DCOM- 20160112
LR  - 20220318
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 173
IP  - 5
DP  - 2015 Nov
TI  - Biomarkers of iron metabolism are independently associated with impaired glucose 
      metabolism and type 2 diabetes: the KORA F4 study.
PG  - 643-53
LID - 10.1530/EJE-15-0631 [doi]
AB  - OBJECTIVE: Iron has been suggested to play a role in the etiology of type 2 
      diabetes mellitus (T2DM). Except for ferritin, evidence is sparse for other 
      markers of iron metabolism that are regulated differently and might act through 
      independent pathways. We therefore investigated the associations of serum 
      ferritin, transferrin, soluble transferrin receptor (sTfR), transferrin 
      saturation (TSAT), sTfR-to-log10ferritin (sTfR-F) index, and iron with impaired 
      glucose metabolism (IGM/'prediabetes'), T2DM, and four continuous glucose and 
      insulin traits. DESIGN AND METHODS: Data from 2893 participants of the 
      population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 
      study (Germany) was investigated through regression analysis. The results were 
      adjusted for socio-demographic, life-style, and obesity measures as well as 
      metabolic, inflammatory, and other iron biomarkers following a step-wise 
      approach. Non-linearity was tested by adding a non-linear spline component to the 
      model. RESULTS: Ferritin and transferrin were positively associated with IGM 
      (fourth vs first sex-specific quartile: ferritin odds ratio (OR)=2.08 (95% CI 
      1.43-3.04) and transferrin OR=1.89 (95% CI 1.32-2.70)), T2DM (ferritin OR=1.98 
      (95% CI 1.22-3.22) and transferrin OR=2.42 (95% CI 1.54-3.81)), and fasting as 
      well as 2-h glucose. TSAT (OR=0.55 (95% CI 0.34-0.88)) and iron (OR=0.61 (95% CI 
      0.38-0.97)) were inversely associated with T2DM, sTfR-F-index was inversely 
      associated with IGM (OR=0.67 (95% CI 0.48-0.95)). There was no strong evidence 
      for non-linear relationships. CONCLUSIONS: The observed associations of several 
      markers of iron metabolism with hyperglycemia and insulin resistance suggest that 
      iron stores as well as iron-related metabolic pathways contribute to the 
      pathogenesis of IGM and T2DM. Moreover, TSAT levels are decreased in T2DM 
      patients.
CI  - (c) 2015 European Society of Endocrinology.
FAU - Huth, Cornelia
AU  - Huth C
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Beuerle, Simon
AU  - Beuerle S
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Zierer, Astrid
AU  - Zierer A
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Heier, Margit
AU  - Heier M
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Herder, Christian
AU  - Herder C
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Kaiser, Thorsten
AU  - Kaiser T
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Koenig, Wolfgang
AU  - Koenig W
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Kronenberg, Florian
AU  - Kronenberg F
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Oexle, Konrad
AU  - Oexle K
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Rathmann, Wolfgang
AU  - Rathmann W
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Roden, Michael
AU  - Roden M
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Schwab, Sigrid
AU  - Schwab S
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany.
FAU - Seissler, Jochen
AU  - Seissler J
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Stockl, Doris
AU  - Stockl D
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Meisinger, Christa
AU  - Meisinger C
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Peters, Annette
AU  - Peters A
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
FAU - Thorand, Barbara
AU  - Thorand B
AD  - Institute of Epidemiology IIHelmholtz Zentrum Munchen, German Research Center for 
      Environmental Health (GmbH), Ingolstaedter Landstrasse 1, D-85764 Neuherberg, 
      GermanyGerman Center for Diabetes Research (DZD)Partner Neuherberg, 
      GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of Augsburg, 
      Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes Center, 
      Leibniz Center for Diabetes Research, Heinrich Heine University Dusseldorf, 
      Dusseldorf, GermanyGerman Center for Diabetes Research (DZD)Partner Dusseldorf, 
      GermanyInstitute of Laboratory MedicineClinical Chemistry and Molecular 
      Diagnostics, University Leipzig, Leipzig, GermanyDepartment of Internal Medicine 
      II - CardiologyUniversity of Ulm Medical Center, Ulm, GermanyDivision of Genetic 
      EpidemiologyDepartment of Medical Genetics, Molecular and Clinical Pharmacology, 
      Medical University of Innsbruck, Innsbruck, AustriaInstitute of Human 
      GeneticsKlinikum Rechts der Isar, Technische Universitat Munchen, Munich, 
      GermanyInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz 
      Center for Diabetes Research, Heinrich Heine University Dusseldorf, Dusseldorf, 
      GermanyDepartment of Endocrinology and DiabetologyMedical Faculty, Heinrich Heine 
      University Dusseldorf, Dusseldorf, GermanyMedizinische Klinik und Poliklinik 
      IVDiabetes Zentrum - Campus Innenstadt, Klinikum der 
      Ludwig-Maximilians-Universitat, Munchen, GermanyClinical Cooperation Group 
      DiabetesLudwig-Maximilians-Universitat Munchen and Helmholtz Zentrum Munchen, 
      Munchen, Germany Institute of Epidemiology IIHelmholtz Zentrum Munchen, German 
      Research Center for Environmental Health (GmbH), Ingolstaedter Landstrasse 1, 
      D-85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD)Partner 
      Neuherberg, GermanyMONICA/KORA Myocardial Infarction RegistryCentral Hospital of 
      Augsburg, Augsburg, GermanyInstitute for Clinical DiabetologyGerman Diabetes 
      Center, Leibniz Center for Diabetes Research, Heinrich Heine University
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150820
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Transferrin)
RN  - 0 (Transferrin)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood/metabolism
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*metabolism
MH  - Female
MH  - Ferritins/blood/*metabolism
MH  - Germany/epidemiology
MH  - Humans
MH  - Iron/blood/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Receptors, Transferrin/blood/*metabolism
MH  - Transferrin/*metabolism
EDAT- 2015/08/22 06:00
MHDA- 2016/01/13 06:00
CRDT- 2015/08/22 06:00
PHST- 2015/06/25 00:00 [received]
PHST- 2015/08/20 00:00 [accepted]
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2016/01/13 06:00 [medline]
AID - EJE-15-0631 [pii]
AID - 10.1530/EJE-15-0631 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2015 Nov;173(5):643-53. doi: 10.1530/EJE-15-0631. Epub 2015 Aug 
      20.