PMID- 26295162
OWN - NLM
STAT- MEDLINE
DCOM- 20160415
LR  - 20211203
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 9
IP  - 8
DP  - 2015
TI  - Type 2 Diabetes Mellitus Is Associated with Strongyloides stercoralis Treatment 
      Failure in Australian Aboriginals.
PG  - e0003976
LID - 10.1371/journal.pntd.0003976 [doi]
LID - e0003976
AB  - OBJECTIVE: To explore the efficacy of ivermectin in the treatment of 
      serologically diagnosed cases of Strongyloides stercoralis (S. stercoralis) 
      infection in an Aboriginal community and to describe factors that may influence 
      the outcome of treatment. METHODS: Longitudinal study of a group of 92 
      individuals with serologically diagnosed S. stercoralis treated with ivermectin 
      and followed up over a period of approximately 6 months. Main outcomes were 
      serological titers pre and post treatment, diabetic status, and duration of 
      follow up. FINDINGS: Treatment success was achieved in 62% to 79% of cases 
      dependent on the methods employed for the diagnosis of infection and assessment 
      of treatment outcome. Type 2 Diabetes Mellitus (T2DM) was found to be 
      significantly associated with treatment failure in this group for two of the 
      three methods employed. INTERPRETATION: Ivermectin has been confirmed as an 
      effective treatment for S stercoralis infection in this setting. T2DM appears to 
      be an independent risk factor for treatment failure in this population, and 
      plausible mechanisms to explain this observation are presented.
FAU - Hays, Russell
AU  - Hays R
AD  - Kimberley Aboriginal Medical Council, Broome, Western Australia, Australia; James 
      Cook University, Cairns Campus, Smithfield, Queensland, Australia.
FAU - Esterman, Adrian
AU  - Esterman A
AD  - Centre for Research Excellence in Chronic Disease Prevention, The Cairns 
      Institute, James Cook University, Cairns Campus, Smithfield, Queensland, 
      Australia; Sansom Institute of Health Service Research and School of Nursing and 
      Midwifery, University of South Australia City East Campus, Adelaide, South 
      Australia, Australia.
FAU - McDermott, Robyn
AU  - McDermott R
AD  - Centre for Chronic Disease Prevention, Australian Institute of Tropical Health 
      and Medicine, College of Public Health, Medical and Veterinary Sciences, James 
      Cook University, Cairns, Queensland, Australia; School of Population Health, 
      University of South Australia, Adelaide, South Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150821
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Antiparasitic Agents)
RN  - 70288-86-7 (Ivermectin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antiparasitic Agents/administration & dosage/*therapeutic use
MH  - Australia/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology/ethnology
MH  - Humans
MH  - Ivermectin/administration & dosage/*therapeutic use
MH  - Longitudinal Studies
MH  - *Native Hawaiian or Other Pacific Islander
MH  - Strongyloides stercoralis/*drug effects
MH  - Strongyloidiasis/*drug therapy
MH  - Treatment Failure
PMC - PMC4546619
COIS- The authors have declared that no competing interests exist.
EDAT- 2015/08/22 06:00
MHDA- 2016/04/16 06:00
PMCR- 2015/08/21
CRDT- 2015/08/22 06:00
PHST- 2015/03/13 00:00 [received]
PHST- 2015/07/12 00:00 [accepted]
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2016/04/16 06:00 [medline]
PHST- 2015/08/21 00:00 [pmc-release]
AID - PNTD-D-15-00413 [pii]
AID - 10.1371/journal.pntd.0003976 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2015 Aug 21;9(8):e0003976. doi: 10.1371/journal.pntd.0003976. 
      eCollection 2015.