PMID- 26296047
OWN - NLM
STAT- MEDLINE
DCOM- 20160729
LR  - 20151012
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 201
DP  - 2015 Dec 15
TI  - Statins do not increase the risk of developing type 2 diabetes in familial 
      hypercholesterolemia: The SAFEHEART study.
PG  - 79-84
LID - S0167-5273(15)30228-X [pii]
LID - 10.1016/j.ijcard.2015.07.107 [doi]
AB  - BACKGROUND: Familial Hypercholesterolemia (FH) is the most common monogenic 
      disorder that causes premature coronary artery disease (CAD). Our objective was 
      to examine the risk of new onset type 2 diabetes mellitus (T2DM) among FH 
      patients and unaffected relatives in relation to treatment with different statins 
      in the SAFEHEART cohort study. METHODS: This is a cross-sectional and prospective 
      cohort study in 2558 FH and 1265 unaffected relatives with a mean follow-up of 
      5.9 years. Several pertinent data, such as age, gender, metabolic syndrome, lipid 
      profile, body mass index (BMI), waist circumference, HOMA-IR, dose, duration and 
      type of statins, were obtained and examined as predictors of incident diabetes. 
      RESULTS: The new onset diabetes was 1.7% in FH and 0.2% in non FH patients 
      (p=0.001). In multivariate logistic regression, age (OR 1.02, CI 95%: 1.02-1.08), 
      HOMA-IR (OR 1.17, CI 95%: 1.03-1.33), metabolic syndrome (OR 3.3, CI 95%: 
      1.32-8.28) and specifically plasma glucose, as a component of metabolic syndrome 
      (OR 15.7, CI 95%: 4.70-52.53) were significant predictors of new onset T2DM in 
      the FH group alone. In the adjusted Cox regression model in FH group, age (HR 
      1.03, CI 95% 1.00-1.06, p=0.031) and metabolic syndrome (HR 4.16, CI 95% 
      1.58-10.92, p=0.004) remained significant predictors of new onset T2DM. 
      CONCLUSIONS: Our data do not support the postulated diabetogenic effect 
      associated with high-dose statins use in our cohort of FH patients.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Fuentes, Francisco
AU  - Fuentes F
AD  - IMIBIC/Hospital Universitario Reina Sofia/Universidad de Cordoba, Cordoba, Spain; 
      CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud 
      Carlos III, Cordoba, Spain. Electronic address: fjfuentesjimenez@gmail.com.
FAU - Alcala-Diaz, Juan F
AU  - Alcala-Diaz JF
AD  - IMIBIC/Hospital Universitario Reina Sofia/Universidad de Cordoba, Cordoba, Spain; 
      CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud 
      Carlos III, Cordoba, Spain.
FAU - Watts, Gerald F
AU  - Watts GF
AD  - Lipid Disorders Clinic, Centre for Cardiovascular Medicine, Royal Perth Hospital, 
      Australia; School of Medicine and Pharmacology, University of Western Australia, 
      Perth, Australia.
FAU - Alonso, Rodrigo
AU  - Alonso R
AD  - Fundacion Hipercolesterolemia Familiar, Madrid, Spain.
FAU - Muniz, Ovidio
AU  - Muniz O
AD  - Department of Internal Medicine, Hospital Virgen del Rocio, Sevilla, Spain.
FAU - Diaz-Diaz, Jose L
AU  - Diaz-Diaz JL
AD  - Department of Internal Medicine, Hospital Abente y Lago, A Coruna, Spain.
FAU - Mata, Nelva
AU  - Mata N
AD  - Department of Epidemiology, Madrid Health Authority, Madrid, Spain.
FAU - Sanchez Munoz-Torrero, Juan F
AU  - Sanchez Munoz-Torrero JF
AD  - Hospital San Pedro de Alcantara, Caceres, Spain.
FAU - Brea, Angel
AU  - Brea A
AD  - Hospital San Pedro Logrono, Spain.
FAU - Galiana, Jesus
AU  - Galiana J
AD  - Hospital General Universitario Ciudad Real, Spain.
FAU - Figueras, Rosaura
AU  - Figueras R
AD  - Hospital Universitario de Bellvitge, Spain.
FAU - Aguado, Rocio
AU  - Aguado R
AD  - Department of Endocrinology, Hospital General de Leon, Spain.
FAU - Piedecausa, Mar
AU  - Piedecausa M
AD  - Department of Internal Medicine, Hospital Universitario de Elche, Spain.
FAU - Cepeda, Jose M
AU  - Cepeda JM
AD  - Department of Internal Medicine, Hospital de Vega Baja, Orihuela, Spain.
FAU - Vidal, Juan I
AU  - Vidal JI
AD  - Department of Endocrinology, Hospital Universitario de Lugo, Spain.
FAU - Rodriguez-Cantalejo, Fernando
AU  - Rodriguez-Cantalejo F
AD  - Laboratory Clinical Analysis, Hospital Universitario Reina Sofia, Cordoba, Spain.
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
AD  - IMIBIC/Hospital Universitario Reina Sofia/Universidad de Cordoba, Cordoba, Spain; 
      CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud 
      Carlos III, Cordoba, Spain.
FAU - Mata, Pedro
AU  - Mata P
AD  - Fundacion Hipercolesterolemia Familiar, Madrid, Spain. Electronic address: 
      pmata@colesterolfamiliar.org.
CN  - SAFEHEART Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150805
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
CIN - Int J Cardiol. 2016 Jan 1;202:954-5. PMID: 26549563
CIN - Int J Cardiol. 2016 Jan 15;203:575. PMID: 26569367
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/chemically induced/*diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use
MH  - Hyperlipoproteinemia Type II/diagnosis/*drug therapy/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Familial hypercholesterolemia
OT  - Statins
OT  - Type 2 diabetes
FIR - Almagro, Fatima
IR  - Almagro F
FIR - Argueso, Rosa
IR  - Argueso R
FIR - Vidal, Juan I
IR  - Vidal JI
FIR - de Andres, Raimundo
IR  - de Andres R
FIR - Arrieta, Francisco
IR  - Arrieta F
FIR - Barba, Miguel Angel
IR  - Barba MA
FIR - Cepeda, Jose Maria
IR  - Cepeda JM
FIR - Pinto, Xavier
IR  - Pinto X
FIR - Irigoyen, Luis
IR  - Irigoyen L
FIR - Martinez-Faedo, Ceferino
IR  - Martinez-Faedo C
FIR - Pereyra, Francisca
IR  - Pereyra F
FIR - Martin, Alberto
IR  - Martin A
FIR - Ruiz, Enrique
IR  - Ruiz E
FIR - Saez, Pedro
IR  - Saez P
FIR - Miramontes, Pablo
IR  - Miramontes P
FIR - Tuson, Carmen
IR  - Tuson C
FIR - Villar, Aurelia
IR  - Villar A
FIR - Zambon, Daniel
IR  - Zambon D
FIR - Garrido, Juan Antonio
IR  - Garrido JA
EDAT- 2015/08/22 06:00
MHDA- 2016/07/30 06:00
CRDT- 2015/08/22 06:00
PHST- 2015/03/02 00:00 [received]
PHST- 2015/07/01 00:00 [revised]
PHST- 2015/07/31 00:00 [accepted]
PHST- 2015/08/22 06:00 [entrez]
PHST- 2015/08/22 06:00 [pubmed]
PHST- 2016/07/30 06:00 [medline]
AID - S0167-5273(15)30228-X [pii]
AID - 10.1016/j.ijcard.2015.07.107 [doi]
PST - ppublish
SO  - Int J Cardiol. 2015 Dec 15;201:79-84. doi: 10.1016/j.ijcard.2015.07.107. Epub 
      2015 Aug 5.