PMID- 26297944
OWN - NLM
STAT- MEDLINE
DCOM- 20160601
LR  - 20170923
IS  - 1878-1810 (Electronic)
IS  - 1878-1810 (Linking)
VI  - 168
DP  - 2016 Feb
TI  - Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials 
      and future perspectives.
PG  - 74-95
LID - S1931-5244(15)00256-X [pii]
LID - 10.1016/j.trsl.2015.07.008 [doi]
AB  - Dendritic cells (DCs) are versatile elements of the immune system and are best 
      known for their unparalleled ability to initiate and modulate adaptive immune 
      responses. During the past few decades, DCs have been the subject of numerous 
      studies seeking new immunotherapeutic strategies against cancer. Despite the 
      initial enthusiasm, disappointing results from early studies raised some doubts 
      regarding the true clinical value of these approaches. However, our expanding 
      knowledge of DC immunobiology and the definition of the optimal characteristics 
      for antitumor immune responses have allowed a more rational development of 
      DC-based immunotherapies in recent years. Here, after a brief overview of DC 
      immunobiology, we sought to systematize the knowledge provided by 20 years of 
      clinical trials, with a special emphasis on the diversity of approaches used to 
      manipulate DCs and their consequent impact on vaccine effectiveness. We also 
      address how new therapeutic concepts, namely the combination of DC vaccines with 
      other anticancer therapies, are being implemented and are leveraging clinical 
      outcomes. Finally, optimization strategies, new insights, and future perspectives 
      on the field are also highlighted.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Constantino, Joao
AU  - Constantino J
AD  - Faculty of Pharmacy and Centre for Neuroscience and Cell Biology (CNC), 
      University of Coimbra, Coimbra, Portugal.
FAU - Gomes, Celia
AU  - Gomes C
AD  - Faculty of Medicine, Laboratory of Pharmacology and Experimental Therapeutics, 
      Institute for Biomedical Imaging and Life Sciences (IBILI) and Center of 
      Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of 
      Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal.
FAU - Falcao, Amilcar
AU  - Falcao A
AD  - Faculty of Pharmacy and Centre for Neuroscience and Cell Biology (CNC), 
      University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, 
      Coimbra, Portugal.
FAU - Cruz, Maria T
AU  - Cruz MT
AD  - Faculty of Pharmacy and Centre for Neuroscience and Cell Biology (CNC), 
      University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, 
      Coimbra, Portugal.
FAU - Neves, Bruno M
AU  - Neves BM
AD  - Faculty of Pharmacy and Centre for Neuroscience and Cell Biology (CNC), 
      University of Coimbra, Coimbra, Portugal; CNC.IBILI, University of Coimbra, 
      Coimbra, Portugal; Department of Chemistry and QOPNA, Mass Spectrometry Centre, 
      University of Aveiro, Aveiro, Portugal. Electronic address: bruno.neves@ua.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150803
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Animals
MH  - Cancer Vaccines/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Neoplasms/*prevention & control
EDAT- 2015/08/25 06:00
MHDA- 2016/06/02 06:00
CRDT- 2015/08/23 06:00
PHST- 2015/05/19 00:00 [received]
PHST- 2015/07/25 00:00 [revised]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/08/23 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/06/02 06:00 [medline]
AID - S1931-5244(15)00256-X [pii]
AID - 10.1016/j.trsl.2015.07.008 [doi]
PST - ppublish
SO  - Transl Res. 2016 Feb;168:74-95. doi: 10.1016/j.trsl.2015.07.008. Epub 2015 Aug 3.