PMID- 26297950
OWN - NLM
STAT- MEDLINE
DCOM- 20151127
LR  - 20150908
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 465
IP  - 3
DP  - 2015 Sep 25
TI  - Differential caspase activity in the cortex and striatum with chronic infusion of 
      3-nitropropionic acid.
PG  - 631-7
LID - S0006-291X(15)30465-4 [pii]
LID - 10.1016/j.bbrc.2015.08.075 [doi]
AB  - Systemic administration of 3-nitropropionic acid (3-NP) facilitates the 
      development of select striatal lesions, and some reports provide clues about this 
      pathology. In this study, we investigated the relationship between reduced levels 
      of brain-derived neurotrophic factor (BDNF) in lesioned brain regions and caspase 
      activity, as well as involvement of apoptosis signal-regulating kinase 1 (ASK1) 
      in caspase activation. We analyzed apoptotic cell death, BDNF distribution, 
      caspase-3 activity, caspase-6 activity, ASK1 expression level, and active ASK1 in 
      the cortex and striatum. There were different levels and distributions of these 
      factors within each sub-region. Caspase-6 activity was reduced with 
      down-regulation of ASK1 in the cortex. BDNF protein levels did not decrease in 
      the cortex, but there was replenishment of severely reduced BDNF in the striatum. 
      The present study suggests that an increase in ASK1 in the damaged cortex is 
      related to caspase-6 activation and is involved in cortical depletion of BDNF in 
      the striatum. Furthermore, with systemic infusion of 3-NP, differential 
      expression of ASK1 in the cortex and striatum suggests that this kinase may 
      modulate caspase activation and striatal degeneration.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Cho, Kyoung Joo
AU  - Cho KJ
AD  - Department of Neurology, Severance Hospital, Yonsei University College of 
      Medicine, 50 Yonsei-ro, Seoul, South Korea.
FAU - Kim, Gyung Whan
AU  - Kim GW
AD  - Department of Neurology, Severance Hospital, Yonsei University College of 
      Medicine, 50 Yonsei-ro, Seoul, South Korea. Electronic address: gyungkim@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20150820
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nitro Compounds)
RN  - 0 (Propionates)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinase 5)
RN  - EC 2.7.11.25 (Map3k5 protein, mouse)
RN  - EC 3.4.22.- (Caspases)
RN  - QY4L0FOX0D (3-nitropropionic acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caspases/*metabolism
MH  - Cerebral Cortex/drug effects/*enzymology
MH  - Corpus Striatum/drug effects/*enzymology
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Activation/drug effects
MH  - Infusions, Intraventricular
MH  - MAP Kinase Kinase Kinase 5/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nitro Compounds/*administration & dosage
MH  - Propionates/*administration & dosage
OTO - NOTNLM
OT  - 3-Nitropropionic acid
OT  - Apoptosis signal-regulating kinase 1
OT  - Caspase-3
OT  - Caspase-6
OT  - siRNA
EDAT- 2015/08/25 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/08/23 06:00
PHST- 2015/08/10 00:00 [received]
PHST- 2015/08/17 00:00 [accepted]
PHST- 2015/08/23 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0006-291X(15)30465-4 [pii]
AID - 10.1016/j.bbrc.2015.08.075 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2015 Sep 25;465(3):631-7. doi: 
      10.1016/j.bbrc.2015.08.075. Epub 2015 Aug 20.