PMID- 26298258
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20151010
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 538
DP  - 2015 Dec 15
TI  - Levels and predictors of persistent organic pollutants in an adult population 
      from four Spanish regions.
PG  - 152-61
LID - S0048-9697(15)30499-X [pii]
LID - 10.1016/j.scitotenv.2015.07.162 [doi]
AB  - This research aimed to assess serum concentrations of a group of persistent 
      organic pollutants (POPs) in a sample of adults recruited in four different 
      regions from Spain and to assess socio-demographic, dietary, and lifestyle 
      predictors of the exposure. The study population comprised 312 healthy adults 
      selected from among controls recruited in the MCC-Spain multicase-control study. 
      Study variables were collected using standardized questionnaires, and pollutants 
      were analyzed by means of gas chromatography with electron capture detection. 
      Multivariable analyses were performed to identify predictors of log-transformed 
      pollutant concentrations, using combined backward and forward stepwise multiple 
      linear regression models. Detection rates ranged from 89.1% (hexachlorobenzene, 
      HCB) to 93.6% (Polychlorinated biphenyl-153 [PCB-153]); 
      p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) showed the highest median 
      concentrations (1.04ng/ml), while HCB showed the lowest (0.24ng/ml). In the 
      multivariable models, age was positively associated with HCB, p,p'-DDE, and 
      PCB-180. BMI was associated positively with p,p'-DDE but negatively with PCB-138. 
      Total accumulated time residing in an urban area was positively associated with 
      PCB-153 concentrations. The women showed higher HCB and lower p,p'-DDE 
      concentrations versus the men. Notably, POP exposure in our study population was 
      inversely associated with the breastfeeding received by participants and with the 
      number of pregnancies of their mothers but was not related to the participants' 
      history of breastfeeding their children or parity. Smoking was negatively 
      associated with HCB and PCB-153 concentrations. Consumption of fatty foods, 
      including blue fish, was in general positively associated with POP levels. 
      Although POP environmental levels are declining worldwide, there is a need for 
      the continuous monitoring of human exposure in the general population. The 
      results of the present study confirm previous findings and point to novel 
      predictors of long-term exposure to persistent organic pollutants.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Fernandez-Rodriguez, M
AU  - Fernandez-Rodriguez M
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain. Electronic address: mafero@ugr.es.
FAU - Arrebola, J P
AU  - Arrebola JP
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain; Oncology Unit, Virgen de las Nieves 
      University Hospital, Granada, Spain; Consortium for Biomedical Research in 
      Epidemiology & Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 
      Spain. Electronic address: jparrebola@ugr.es.
FAU - Artacho-Cordon, F
AU  - Artacho-Cordon F
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain.
FAU - Amaya, E
AU  - Amaya E
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain.
FAU - Aragones, N
AU  - Aragones N
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; Cancer Epidemiology Unit, National 
      Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain; Cancer 
      Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro 
      (IDIPHIM), Majadahonda, Madrid, Spain.
FAU - Llorca, J
AU  - Llorca J
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; Universidad de Cantabria-IDIVAL, 
      Santander, Spain.
FAU - Perez-Gomez, B
AU  - Perez-Gomez B
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; Cancer Epidemiology Unit, National 
      Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain; Cancer 
      Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro 
      (IDIPHIM), Majadahonda, Madrid, Spain.
FAU - Ardanaz, E
AU  - Ardanaz E
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; Navarra Public Health Institute, 
      Pamplona, Spain; Navarra Institute for Health Research (IdiSNA) Pamplona, Spain.
FAU - Kogevinas, M
AU  - Kogevinas M
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; IMIM (Hospital del Mar Medical 
      Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, 
      Spain; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, 
      Spain.
FAU - Castano-Vinyals, G
AU  - Castano-Vinyals G
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; IMIM (Hospital del Mar Medical 
      Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, 
      Spain; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, 
      Spain.
FAU - Pollan, M
AU  - Pollan M
AD  - Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Madrid, Spain; Cancer Epidemiology Unit, National 
      Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain; Cancer 
      Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro 
      (IDIPHIM), Majadahonda, Madrid, Spain.
FAU - Olea, N
AU  - Olea N
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain; Consortium for Biomedical Research 
      in Epidemiology & Public Health (CIBERESP), Instituto de Salud Carlos III, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150822
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Diet/statistics & numerical data
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Spain
OTO - NOTNLM
OT  - Exposure predictors
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
EDAT- 2015/08/25 06:00
MHDA- 2016/07/14 06:00
CRDT- 2015/08/24 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/07/31 00:00 [revised]
PHST- 2015/07/31 00:00 [accepted]
PHST- 2015/08/24 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
AID - S0048-9697(15)30499-X [pii]
AID - 10.1016/j.scitotenv.2015.07.162 [doi]
PST - ppublish
SO  - Sci Total Environ. 2015 Dec 15;538:152-61. doi: 10.1016/j.scitotenv.2015.07.162. 
      Epub 2015 Aug 22.