PMID- 26298785
OWN - NLM
STAT- MEDLINE
DCOM- 20160615
LR  - 20150824
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 16
IP  - 9
DP  - 2015 Sep
TI  - Sleep-disordered breathing in chronic heart failure: development and validation 
      of a clinical screening score.
PG  - 1094-101
LID - S1389-9457(15)00632-2 [pii]
LID - 10.1016/j.sleep.2014.11.022 [doi]
AB  - AIMS: Sleep-disordered breathing (SDB) is highly prevalent and of adverse 
      prognostic significance in patients with chronic heart failure (CHF). Polygraphy 
      is used for diagnosing SDB but polygraphy resources fall short of needs. Here, 
      our aim was to develop a score for SDB screening in patients with CHF. METHODS 
      AND RESULTS: Consecutive patients with stable chronic CHF referred to our CHF 
      clinic for a scheduled follow-up evaluation were included prospectively between 
      2000 and 2012. SDB was defined as an apnoea-hypopnoea index >/= 5/h as assessed by 
      routine polygraphy. A screening score was developed as a linear combination of 
      factors independently associated with SDB by multivariate logistic regression. 
      Calibration and discrimination were evaluated using the Hosmer-Lemeshow (HL) test 
      and area under the receiver-operating characteristics curve (AUC), respectively. 
      Bootstrapping was performed to assess internal validity. Of 450 included patients 
      (mean age, 59.5 +/- 13.7 years), 397 (88%) had SDB. An easy-to-use score was based 
      on age (2 points if >/=65 years), body mass index (2 points if >/=25 kg/m(2)), New 
      York Heart Association (NYHA) class (2 points if >/=3 or 4) and male gender (3 
      points). A score cut-off of 5 was 78.9% sensitive and 61.5% specific for SDB. The 
      final model exhibited adequate calibration (pHL >/= 0.3) and discrimination (AUC, 
      0.737; 95% confidence interval, 0.663; 0.810). CONCLUSION: An easy-to-use 
      clinical score combining age, body mass index, NYHA class, and gender may help to 
      identify those CHF patients most likely to have SDB, thereby improving the 
      allocation of scarce polygraphy resources and early diagnosis of SDB.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Parisot, Juliette
AU  - Parisot J
AD  - Public Health Department, APHP, Henri-Mondor Teaching Hospital, Creteil, F-94000, 
      France; UPEC, Laboratoire d'Investigation Clinique (LIC), EA 4393, Creteil 
      F-94000, France; INSERM Clinical Investigation Centre 006, Paris F-75000, France; 
      Department of Clinical research and Public Health, Clinical Investigation Centre 
      006, Paris F-75000, France.
FAU - Damy, Thibaud
AU  - Damy T
AD  - APHP, Department of Cardiology, Henri-Mondor Teaching Hospital, Creteil F-94000, 
      France; INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, 
      Creteil F-94000, France; GRC Reseau Amylose Mondor at Henri mondor Teaching 
      Hospital, Creteil F-94000, France. Electronic address: thibaud.damy@hmn.aphp.fr.
FAU - Gellen, Barnabas
AU  - Gellen B
AD  - INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, Creteil 
      F-94000, France; GRC Reseau Amylose Mondor at Henri mondor Teaching Hospital, 
      Creteil F-94000, France; APHP, Service de Physiologie- Explorations 
      Fonctionnelles, Henri-Mondor Teaching Hospital, Creteil F-94000, France.
FAU - Covali-Noroc, Ala
AU  - Covali-Noroc A
AD  - APHP, Service de Physiologie- Explorations Fonctionnelles, Henri-Mondor Teaching 
      Hospital, Creteil F-94000, France.
FAU - Bodez, Diane
AU  - Bodez D
AD  - APHP, Department of Cardiology, Henri-Mondor Teaching Hospital, Creteil F-94000, 
      France; INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, 
      Creteil F-94000, France; GRC Reseau Amylose Mondor at Henri mondor Teaching 
      Hospital, Creteil F-94000, France.
FAU - Rappeneau, Stephane
AU  - Rappeneau S
AD  - APHP, Department of Cardiology, Henri-Mondor Teaching Hospital, Creteil F-94000, 
      France; UPEC, DHU ATVB, Creteil F-94000, France; GRC Reseau Amylose Mondor at 
      Henri mondor Teaching Hospital, Creteil F-94000, France.
FAU - Guellich, Aziz
AU  - Guellich A
AD  - APHP, Department of Cardiology, Henri-Mondor Teaching Hospital, Creteil F-94000, 
      France; UPEC, DHU ATVB, Creteil F-94000, France.
FAU - Adnot, Serge
AU  - Adnot S
AD  - INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, Creteil 
      F-94000, France; APHP, Service de Physiologie- Explorations Fonctionnelles, 
      Henri-Mondor Teaching Hospital, Creteil F-94000, France.
FAU - Bastuji-Garin, Sylvie
AU  - Bastuji-Garin S
AD  - Public Health Department, APHP, Henri-Mondor Teaching Hospital, Creteil, F-94000, 
      France; UPEC, Laboratoire d'Investigation Clinique (LIC), EA 4393, Creteil 
      F-94000, France; INSERM Clinical Investigation Centre 006, Paris F-75000, France; 
      Department of Clinical research and Public Health, Clinical Investigation Centre 
      006, Paris F-75000, France; APHP, Clinical Research Unit (URC-Mondor), 
      Henri-Mondor Teaching Hospital, Creteil F-94000, France.
FAU - Hittinger, Luc
AU  - Hittinger L
AD  - APHP, Department of Cardiology, Henri-Mondor Teaching Hospital, Creteil F-94000, 
      France; INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, 
      Creteil F-94000, France; GRC Reseau Amylose Mondor at Henri mondor Teaching 
      Hospital, Creteil F-94000, France.
FAU - d'Ortho, Maria-Pia
AU  - d'Ortho MP
AD  - APHP, DHU Fire, Centre du Sommeil, Physiologie - Explorations Fonctionnelles, 
      Bichat Teaching Hospital, Paris F-75000, France; Universite Paris-Diderot Paris 
      7, Paris F-75000, France.
FAU - Boyer, Laurent
AU  - Boyer L
AD  - INSERM, Unite U955 (team 8), Creteil F-94000, France; UPEC, DHU ATVB, Creteil 
      F-94000, France; APHP, Service de Physiologie- Explorations Fonctionnelles, 
      Henri-Mondor Teaching Hospital, Creteil F-94000, France.
FAU - Canoui-Poitrine, Florence
AU  - Canoui-Poitrine F
AD  - Public Health Department, APHP, Henri-Mondor Teaching Hospital, Creteil, F-94000, 
      France; UPEC, Laboratoire d'Investigation Clinique (LIC), EA 4393, Creteil 
      F-94000, France; INSERM Clinical Investigation Centre 006, Paris F-75000, France; 
      Department of Clinical research and Public Health, Clinical Investigation Centre 
      006, Paris F-75000, France.
LA  - eng
PT  - Journal Article
DEP - 20150330
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*complications
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Polysomnography
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Risk Assessment
MH  - Sex Factors
MH  - Sleep Apnea Syndromes/*diagnosis/*etiology
OTO - NOTNLM
OT  - Heart failure
OT  - Polygraphy
OT  - Score
OT  - Sensitivity
OT  - Sleep-disordered breathing (SDB)
OT  - Specificity
EDAT- 2015/08/25 06:00
MHDA- 2016/06/16 06:00
CRDT- 2015/08/24 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2014/10/15 00:00 [revised]
PHST- 2014/11/02 00:00 [accepted]
PHST- 2015/08/24 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/06/16 06:00 [medline]
AID - S1389-9457(15)00632-2 [pii]
AID - 10.1016/j.sleep.2014.11.022 [doi]
PST - ppublish
SO  - Sleep Med. 2015 Sep;16(9):1094-101. doi: 10.1016/j.sleep.2014.11.022. Epub 2015 
      Mar 30.