PMID- 26300387
OWN - NLM
STAT- MEDLINE
DCOM- 20160803
LR  - 20151018
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 77
DP  - 2015 Oct
TI  - Language and motor cortex response to comprehending accidental and intentional 
      action sentences.
PG  - 158-64
LID - S0028-3932(15)30136-6 [pii]
LID - 10.1016/j.neuropsychologia.2015.08.020 [doi]
AB  - Understanding the meaning of others' actions involves mentally simulating those 
      actions by oneself. Embodied theories of language espouse a prominent role for 
      motor simulation in reading comprehension, especially when words, sentences, or 
      narratives portray everyday actions. Inherent in these actions is the level of 
      agency of the actor. Motor cortex activity in response to processing action verbs 
      has been relatively well-established. What has been less explored, however, are: 
      (1) the neural bases of determining whether an action is intentional or 
      accidental (agency); and (2) whether agency influences level of motor simulation. 
      This functional MRI study investigated how language and motor areas of the brain 
      respond to sentences depicting intentional versus accidental action. 25 healthy 
      adults read a series of sentences in the MRI scanner and determined whether the 
      actions described were accidental or intentional. The main results include: (1) 
      left hemisphere language areas (left inferior frontal gyrus, LIFG; left superior 
      temporal gyrus, LSTG), premotor cortex (PM), and presupplementary motor area 
      (pSMA) were strongly activated by both sentence types; (2) processing accidental 
      action, relative to intentional action, elicited greater activity in LIFG, medial 
      prefrontal cortex (MPFC), and left amygdala; no statistically significant 
      activity was found in the opposite contrast; and (3) greater percent signal 
      change was observed in LIFG while processing accidental action and in right 
      precentral gyrus for intentional action. The results of this study support 
      language and motor region involvement in action sentence comprehension in 
      accordance with embodiment theories. Additionally, it provides new insight into 
      the linguistic, integrative, and emotional demands of comprehending accidental 
      action, its underlying neural circuitry, and its relationship to intentionality 
      bias: the predisposition to ascribe purpose to action.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Kana, Rajesh K
AU  - Kana RK
AD  - Departmentof Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA. Electronic address: rkana@uab.edu.
FAU - Ammons, Carla J
AU  - Ammons CJ
AD  - Departmentof Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Doss, Constance F
AU  - Doss CF
AD  - Departmentof Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Waite, Megan E
AU  - Waite ME
AD  - Departmentof Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Kana, Bhumika
AU  - Kana B
AD  - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Herringshaw, Abbey J
AU  - Herringshaw AJ
AD  - Departmentof Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Ver Hoef, Lawrence
AU  - Ver Hoef L
AD  - Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150821
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Mapping
MH  - Cerebral Cortex/*physiology
MH  - Comprehension/*physiology
MH  - Female
MH  - Humans
MH  - Language Tests
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuropsychological Tests
MH  - Pattern Recognition, Visual/*physiology
MH  - Photic Stimulation
MH  - *Reading
MH  - Young Adult
OTO - NOTNLM
OT  - Accidental action
OT  - Embodied cognition
OT  - Intentional action
OT  - Intentionality bias
OT  - Sentence comprehension
OT  - fMRI
EDAT- 2015/08/25 06:00
MHDA- 2016/08/04 06:00
CRDT- 2015/08/25 06:00
PHST- 2015/03/12 00:00 [received]
PHST- 2015/07/15 00:00 [revised]
PHST- 2015/08/19 00:00 [accepted]
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/08/04 06:00 [medline]
AID - S0028-3932(15)30136-6 [pii]
AID - 10.1016/j.neuropsychologia.2015.08.020 [doi]
PST - ppublish
SO  - Neuropsychologia. 2015 Oct;77:158-64. doi: 
      10.1016/j.neuropsychologia.2015.08.020. Epub 2015 Aug 21.