PMID- 26300451
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20181202
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 294
DP  - 2015 Nov 1
TI  - Dopamine and glutamate release in the anterior default system during rest: A 
      monkey microdialysis study.
PG  - 194-7
LID - S0166-4328(15)30146-7 [pii]
LID - 10.1016/j.bbr.2015.08.013 [doi]
AB  - Human neuroimaging studies have demonstrated the presence of a default system in 
      the brain, which shows a default mode of brain activity, i.e., greater activity 
      during rest than during an attention-demanding cognitive task. Our previous study 
      on monkeys has revealed a default mode of brain activity in medial cortical 
      areas. We have observed an increase in dopamine (DA) release during a working 
      memory (WM) task compared with that during rest in the monkey lateral prefrontal 
      cortex (LPFC). However, no previous study has examined DA release related to the 
      default mode of brain activity. We used a microdialysis technique to investigate 
      changes in DA release in the medial prefrontal cortex (MPFC), which constitutes 
      the anterior default system, during the WM task and rest. Because DA and 
      glutamate (Glu) release in the LPFC is interrelated, we also examined Glu release 
      in the MPFC. We observed a significant increase in DA release, but no significant 
      change in Glu release during rest compared with that during the WM task. We also 
      observed an inhibitory relationship between the two transmitters in the MPFC. 
      Considering that human default brain activity is related to internal thought 
      processes and increased DA release in the LPFC plays an important role in 
      executive control, increase in DA release during rest in the monkey anterior 
      default system may be related to some form of internal thought process.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Kodama, Tohru
AU  - Kodama T
AD  - Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical 
      Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan.
FAU - Hikosaka, Kazuo
AU  - Hikosaka K
AD  - Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical 
      Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan; Department of 
      Sensory Science, Faculty of Health Science and Technology, Kawasaki University of 
      Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Japan.
FAU - Honda, Yoshiko
AU  - Honda Y
AD  - Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical 
      Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan.
FAU - Kojima, Takashi
AU  - Kojima T
AD  - Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical 
      Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan.
FAU - Tsutsui, Ken-ichiro
AU  - Tsutsui K
AD  - Division of Systems Neuroscience, Tohoku University Graduate School of Life 
      Sciences, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
FAU - Watanabe, Masataka
AU  - Watanabe M
AD  - Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical 
      Science, 2-1-6 Kamikitazawa, Setagaya, Tokyo 156-8506, Japan. Electronic address: 
      watanabe-ms@igakuken.or.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150820
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 3KX376GY7L (Glutamic Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Catheters, Indwelling
MH  - Dopamine/*metabolism
MH  - Glutamic Acid/*metabolism
MH  - Macaca
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Microdialysis
MH  - Neural Pathways/metabolism
MH  - Neuropsychological Tests
MH  - Photic Stimulation
MH  - Prefrontal Cortex/*metabolism
MH  - Rest/*physiology
OTO - NOTNLM
OT  - Default brain activity
OT  - Dopamine
OT  - Glutamate
OT  - Medial prefrontal cortex
OT  - Rest
EDAT- 2015/08/25 06:00
MHDA- 2016/06/15 06:00
CRDT- 2015/08/25 06:00
PHST- 2015/07/24 00:00 [received]
PHST- 2015/08/13 00:00 [revised]
PHST- 2015/08/15 00:00 [accepted]
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
AID - S0166-4328(15)30146-7 [pii]
AID - 10.1016/j.bbr.2015.08.013 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 Nov 1;294:194-7. doi: 10.1016/j.bbr.2015.08.013. Epub 2015 
      Aug 20.