PMID- 26300543
OWN - NLM
STAT- MEDLINE
DCOM- 20160301
LR  - 20161125
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 606
DP  - 2015 Oct 8
TI  - Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines and 
      depressive-like behavior in mice.
PG  - 1-6
LID - S0304-3940(15)30095-1 [pii]
LID - 10.1016/j.neulet.2015.08.025 [doi]
AB  - The aim of the study was to investigate the effects and possible underlying 
      mechanism of salidroside (Sal) on lipopolysaccharide (LPS)-induced 
      depression-like behavior in mice. Sal (12 mg/kg and 24 mg/kg) and fluoxetine (20 
      mg/kg) were administered intragastrically once daily for 5 days. At the 5th day, 
      LPS (0.5 mg/kg) was injected intraperitoneally 30 min after drug administration. 
      Levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in serum were 
      measured by ELISA. Levels of neurotransmitters like norepinephrine (NE) and 
      5-hydroxytryptamine (5-HT) in the prefrontal cortex were detected by HPLC-MS. 
      Further, brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B 
      (TrkB) and Nuclear factor-kappaB (NF-kappaB) in hippocampal was determined by western 
      blot analysis. Our data showed that pretreatment with Sal dramatically attenuated 
      LPS-induced inflammatory response, decrease of NE and 5-HT levels in the 
      prefrontal cortex. In addition, Sal increased expression levels of BNDF and TrkB. 
      These results suggested that Sal may play a neuroprotective role through the 
      BDNF/TrkB signaling pathway.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhu, Lingpeng
AU  - Zhu L
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China.
FAU - Wei, Tingting
AU  - Wei T
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China.
FAU - Gao, Jing
AU  - Gao J
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China.
FAU - Chang, Xiayun
AU  - Chang X
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China.
FAU - He, He
AU  - He H
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China.
FAU - Miao, Mingxing
AU  - Miao M
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China. Electronic address: miaomingxing25@126.com.
FAU - Yan, Tianhua
AU  - Yan T
AD  - Department of Physiology and Pharmacology, China Pharmaceutical University, 
      Nanjing, China. Electronic address: yantianhuabest@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150820
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Glucosides)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Phenols)
RN  - 333DO1RDJY (Serotonin)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - M983H6N1S9 (rhodioloside)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cytokines/*blood
MH  - Depression/*drug therapy/metabolism/psychology
MH  - Enzyme Activation
MH  - Glucosides/pharmacology/*therapeutic use
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Membrane Glycoproteins/metabolism
MH  - Mice, Inbred ICR
MH  - NF-kappa B/metabolism
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Norepinephrine/metabolism
MH  - Phenols/pharmacology/*therapeutic use
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Serotonin/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Depression
OT  - Inflammation
OT  - Lipopolysaccharide
OT  - Salidroside
EDAT- 2015/08/25 06:00
MHDA- 2016/03/02 06:00
CRDT- 2015/08/25 06:00
PHST- 2015/01/19 00:00 [received]
PHST- 2015/06/18 00:00 [revised]
PHST- 2015/08/14 00:00 [accepted]
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2016/03/02 06:00 [medline]
AID - S0304-3940(15)30095-1 [pii]
AID - 10.1016/j.neulet.2015.08.025 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 Oct 8;606:1-6. doi: 10.1016/j.neulet.2015.08.025. Epub 2015 
      Aug 20.