PMID- 26300882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150824
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - Mast Cells as Regulators of T Cell Responses.
PG  - 394
LID - 10.3389/fimmu.2015.00394 [doi]
LID - 394
AB  - Mast cells (MCs) are recognized to participate in the regulation of innate and 
      adaptive immune responses. Owing to their strategic location at the 
      host-environment interface, they control tissue homeostasis and are key cells for 
      starting early host defense against intruders. Upon degranulation induced, e.g., 
      by immunoglobulin E (IgE) and allergen-mediated engagement of the high-affinity 
      IgE receptor, complement or certain neuropeptide receptors, MCs release a wide 
      variety of preformed and newly synthesized products including proteases, lipid 
      mediators, and many cytokines, chemokines, and growth factors. Interestingly, 
      increasing evidence suggests a regulatory role for MCs in inflammatory diseases 
      via the regulation of T cell activities. Furthermore, rather than only serving as 
      effector cells, MCs are now recognized to induce T cell activation, recruitment, 
      proliferation, and cytokine secretion in an antigen-dependent manner and to 
      impact on regulatory T cells. This review synthesizes recent developments in MC-T 
      cell interactions, discusses their biological and clinical relevance, and 
      explores recent controversies in this field of MC research.
FAU - Bulfone-Paus, Silvia
AU  - Bulfone-Paus S
AD  - Manchester Collaborative Centre for Inflammation Research (MCCIR), Institute of 
      Inflammation and Repair, University of Manchester , Manchester , UK.
FAU - Bahri, Rajia
AU  - Bahri R
AD  - Manchester Collaborative Centre for Inflammation Research (MCCIR), Institute of 
      Inflammation and Repair, University of Manchester , Manchester , UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150807
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4528181
OTO - NOTNLM
OT  - CD4 T cell
OT  - CD8 T cell
OT  - Treg cells
OT  - adaptive immunity
OT  - mast cells
EDAT- 2015/08/25 06:00
MHDA- 2015/08/25 06:01
PMCR- 2015/01/01
CRDT- 2015/08/25 06:00
PHST- 2015/05/31 00:00 [received]
PHST- 2015/07/19 00:00 [accepted]
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2015/08/25 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00394 [doi]
PST - epublish
SO  - Front Immunol. 2015 Aug 7;6:394. doi: 10.3389/fimmu.2015.00394. eCollection 2015.