PMID- 26300948
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150824
LR  - 20181113
IS  - 1742-6405 (Print)
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 12
DP  - 2015
TI  - Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese 
      subjects: a prospective epidemiological investigation.
PG  - 28
LID - 10.1186/s12981-015-0064-9 [doi]
LID - 28
AB  - BACKGROUND: Human leukocyte antigen (HLA)-B*5701 is strongly associated with 
      developing a hypersensitivity reaction to abacavir (ABC). Limited data exist on 
      HLA-B*5701 prevalence in HIV-1-infected subjects in China. We investigated 
      HLA-B*5701 prevalence in HIV-1-infected population including Han and non-Han 
      ethnic groups. METHODS: A prospective multi-centre study was designed to 
      determine status of HLA-B*5701 in HIV-1-infected adults at six sites across 
      China. HLA-B*5701 was tested by the method of PCR-SSP. RESULTS: From six centers, 
      3,000 HIV-infected patients [2,452 (81.7%) Han, 548 (18.3%) Non-Han] were 
      recruited with a mean age of 36.7 years old. The overall HLA-B*5701 prevalence 
      was 0.86% [95% confidence interval (CI) 0.55-1.26%]. The prevalence of HLA-B*5701 
      among Han subjects was similar to that among non-Han subjects, which was 0.88% 
      (95% CI 0.54-1.34%) and 0.76% (95% CI 0.19-1.93%), respectively (p 
      value = 0.787). There were no differences in prevalence of HLA-B*5701 between 
      subjects born in Henan, Yunnan, Shanxi, Guangdong, Hebei, Beijing and other 
      provinces (p = 0.999). CONCLUSIONS: HLA-B*5701 prevalence is very low in 
      HIV-infected Chinese subjects, both in the Han and Non-Han nationalities. And 
      there are no differences among different birthplaces across China.
FAU - Zhang, Hongwei
AU  - Zhang H
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
FAU - Zhang, Tong
AU  - Zhang T
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
FAU - Zhao, Hongxin
AU  - Zhao H
AD  - Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100069 China.
FAU - Han, Ning
AU  - Han N
AD  - Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100069 China.
FAU - Zhou, Haiwei
AU  - Zhou H
AD  - Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100069 China.
FAU - He, Yun
AU  - He Y
AD  - Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, 
      Zhengzhou, 450015 China.
FAU - Zhao, Qingxia
AU  - Zhao Q
AD  - Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, 
      Zhengzhou, 450015 China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Infectious Diseases, The 6th People Hospital of Zhengzhou, 
      Zhengzhou, 450015 China.
FAU - Li, Huiqin
AU  - Li H
AD  - Yunnan AIDS Care Center, Kunming, 650301 China.
FAU - Zhang, Mi
AU  - Zhang M
AD  - Yunnan AIDS Care Center, Kunming, 650301 China.
FAU - Li, Jianjian
AU  - Li J
AD  - Yunnan AIDS Care Center, Kunming, 650301 China.
FAU - Sun, Yongtao
AU  - Sun Y
AD  - Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, 710038 China.
FAU - Zhao, Ke
AU  - Zhao K
AD  - Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, 710038 China.
FAU - Liu, Qing
AU  - Liu Q
AD  - Department of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, 710038 China.
FAU - Liu, Zhiying
AU  - Liu Z
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
FAU - Li, Zhen
AU  - Li Z
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
FAU - Xia, Wei
AU  - Xia W
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
FAU - Lan, Yun
AU  - Lan Y
AD  - Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 
      510060 China.
FAU - Hu, Haolan
AU  - Hu H
AD  - Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 
      510060 China.
FAU - Cai, Weiping
AU  - Cai W
AD  - Department of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou, 
      510060 China.
FAU - Wu, Hao
AU  - Wu H
AD  - Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical 
      University, 8 Xitoutiao, Youanmenwai St., Fengtai Dist., Beijing, 100069 People's 
      Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20150819
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC4543466
OTO - NOTNLM
OT  - HIV
OT  - HLA-B*5701
OT  - Prevalence
EDAT- 2015/08/25 06:00
MHDA- 2015/08/25 06:01
PMCR- 2015/08/19
CRDT- 2015/08/25 06:00
PHST- 2015/01/24 00:00 [received]
PHST- 2015/07/17 00:00 [accepted]
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2015/08/25 06:01 [medline]
PHST- 2015/08/19 00:00 [pmc-release]
AID - 64 [pii]
AID - 10.1186/s12981-015-0064-9 [doi]
PST - epublish
SO  - AIDS Res Ther. 2015 Aug 19;12:28. doi: 10.1186/s12981-015-0064-9. eCollection 
      2015.