PMID- 26301408 OWN - NLM STAT- MEDLINE DCOM- 20161222 LR - 20220321 IS - 1097-6779 (Electronic) IS - 0016-5107 (Linking) VI - 83 IP - 4 DP - 2016 Apr TI - Adverse events of EUS-guided FNA of pancreatic cystic and solid lesions by using the lexicon proposed in an ASGE workshop: a prospective and comparative study. PG - 780-4 LID - S0016-5107(15)02807-2 [pii] LID - 10.1016/j.gie.2015.08.035 [doi] AB - BACKGROUND AND AIMS: Pancreatic cysts and solid lesions are routinely examined by EUS-guided FNA (EUS-FNA). The aim of this study was to compare the incidence of adverse events (AEs) of this procedure by using the lexicon recommended by the American Society for Gastrointestinal Endoscopy (ASGE). METHODS: This was a prospective and comparative study of patients who underwent EUS-FNA in which a 22-gauge needle was used. In the pancreatic cystic lesions group (group I), complete fluid evacuation in a single needle pass was attempted, and ciprofloxacin was given during the procedure and for 3 days after. In the pancreatic solid lesions group (group II), the number of passes was determined by the on-site evaluation of the sample. AEs were defined and graded according to the lexicon recommended by the ASGE. Patients were followed for 48 hours, 1 week, and 1 month after the procedure. RESULTS: A total of 146 patients were included, 73 in group I and 73 in group II. Potential factors influencing the incidence of AEs (ie, access route for FNA) were similar in both groups. AEs occurred in 5 of 146 patients (3.4%; 95% confidence interval [CI], 1.3%-8%): 4 in group I (5.5%; 95% CI, 1.7%-13.7%) and 1 in group II (1.4%; 95% CI, -0.5% to 8.1%) (P = .03). Severity was mild in 1 of 5 patients (20%) and moderate in 3 of 5 patients (60%). One patient with a solid mass in the head of the pancreas had a duodenal perforation after EUS and died after surgery. All other AEs occurred in the first 48 hours and resolved with medical therapy. There were 3 incidents of transient hypoxia and self-limited abdominal pain in 1 and 2 patients, respectively. No patients were lost to follow-up. CONCLUSION: EUS-FNA of pancreatic cysts has an AEs rate similar to that of solid pancreatic masses, which is small enough to consider this procedure a safe and effective method for managing patients with both types of lesions. AEs occurred early after EUS-FNA, and patients should be closely followed during the first 2 days after the procedure. CI - Copyright (c) 2016 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved. FAU - Rodriguez-D'Jesus, Antonio AU - Rodriguez-D'Jesus A AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Fernandez-Esparrach, Gloria AU - Fernandez-Esparrach G AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Marra-Lopez, Carlos AU - Marra-Lopez C AD - Hospital Universitario Araba, Vitoria-Gasteiz, Spain. FAU - Orive-Calzada, Aitor AU - Orive-Calzada A AD - Hospital Universitario Araba, Vitoria-Gasteiz, Spain. FAU - Sendino, Oriol AU - Sendino O AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Araujo, Isis K AU - Araujo IK AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Rodriguez de Miguel, Cristina AU - Rodriguez de Miguel C AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Vazquez-Sequeiros, Enrique AU - Vazquez-Sequeiros E AD - Instituto Ramon y Cajal de Investigacion, Madrid, Spain. FAU - Cordova, Henry AU - Cordova H AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Sanchez-Montes, Cristina AU - Sanchez-Montes C AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Gonzalez-Suarez, Begona AU - Gonzalez-Suarez B AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. FAU - Gines, Angels AU - Gines A AD - Endoscopy Unit, Gastroenterology Department, ICMDM, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain. LA - eng PT - Comparative Study PT - Journal Article DEP - 20150822 PL - United States TA - Gastrointest Endosc JT - Gastrointestinal endoscopy JID - 0010505 SB - IM MH - Abdominal Pain/etiology MH - Aged MH - Duodenal Diseases/*etiology MH - Endoscopic Ultrasound-Guided Fine Needle Aspiration/*adverse effects MH - *Endoscopy, Gastrointestinal MH - Female MH - Humans MH - Hypoxia/etiology MH - Intestinal Perforation/*etiology MH - Male MH - Middle Aged MH - Pancreatic Cyst/*pathology MH - Pancreatic Neoplasms/*pathology MH - Prospective Studies MH - *Societies, Medical MH - *Terminology as Topic EDAT- 2015/08/25 06:00 MHDA- 2016/12/23 06:00 CRDT- 2015/08/25 06:00 PHST- 2015/03/20 00:00 [received] PHST- 2015/08/07 00:00 [accepted] PHST- 2015/08/25 06:00 [entrez] PHST- 2015/08/25 06:00 [pubmed] PHST- 2016/12/23 06:00 [medline] AID - S0016-5107(15)02807-2 [pii] AID - 10.1016/j.gie.2015.08.035 [doi] PST - ppublish SO - Gastrointest Endosc. 2016 Apr;83(4):780-4. doi: 10.1016/j.gie.2015.08.035. Epub 2015 Aug 22.