PMID- 26301802
OWN - NLM
STAT- MEDLINE
DCOM- 20151222
LR  - 20150925
IS  - 1520-6025 (Electronic)
IS  - 0163-3864 (Linking)
VI  - 78
IP  - 9
DP  - 2015 Sep 25
TI  - Lepidotol A from Mesua lepidota Inhibits Inflammatory and Immune Mediators in 
      Human Endothelial Cells.
PG  - 2187-97
LID - 10.1021/acs.jnatprod.5b00222 [doi]
AB  - Phytochemical investigation on the fruits of Mesua lepidota (Calophyllaceae) led 
      to the isolation of seven new phenylcoumarin derivatives named lepidotols A-E 
      (1-5) and lepidotins A and B (6, 7). These structures were elucidated by 
      spectroscopic and spectrometric methods including UV, NMR, and HRMS. Lepidotol A 
      (1), the major compound, was evaluated for its inhibitory effect on inflammation 
      and immunity using endothelial cell-based cellular assays. At 10 muM, 1 exhibited 
      an anti-inflammatory activity, with a significant inhibition of vascular cell 
      adhesion molecule 1 and intercellular adhesion molecule 1 expression induced by 
      tumor necrosis factor-alpha. Lepidotol A also showed a mild immunosuppressive effect, 
      with inhibition of the major histocompatibility complex molecules, namely, human 
      leukocyte antigen (HLA)-DR and HLA-E.
FAU - Rouger, Caroline
AU  - Rouger C
AD  - EA921 SONAS, SFR4207 QUASAV, Universite d'Angers , Angers, France.
FAU - Derbre, Severine
AU  - Derbre S
AD  - EA921 SONAS, SFR4207 QUASAV, Universite d'Angers , Angers, France.
FAU - Charreau, Beatrice
AU  - Charreau B
AD  - INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie , LabEx IGO 
      and LabEx Transplantex, Nantes, France.
AD  - CHU de Nantes, Institut de Transplantation-Urologie-Nephrologie, ITUN , Nantes, 
      France.
AD  - Faculte de Medecine, LUNAM, Universite de Nantes , Nantes, France.
FAU - Pabois, Angelique
AU  - Pabois A
AD  - INSERM UMR1064, Centre de Recherche en Transplantation et Immunologie , LabEx IGO 
      and LabEx Transplantex, Nantes, France.
AD  - CHU de Nantes, Institut de Transplantation-Urologie-Nephrologie, ITUN , Nantes, 
      France.
AD  - Faculte de Medecine, LUNAM, Universite de Nantes , Nantes, France.
FAU - Cauchy, Thomas
AU  - Cauchy T
AD  - Laboratoire MOLTECH-Anjou, CNRS UMR6200, Universite d'Angers , Angers, France.
FAU - Litaudon, Marc
AU  - Litaudon M
AD  - Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN) , 
      CNRS, LabEx CEBA, Gif-sur-Yvette, France.
FAU - Awang, Khalijah
AU  - Awang K
AD  - Department of Chemistry, Faculty of Science, University of Malaya , Kuala Lumpur, 
      Malaysia.
FAU - Richomme, Pascal
AU  - Richomme P
AD  - EA921 SONAS, SFR4207 QUASAV, Universite d'Angers , Angers, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150824
PL  - United States
TA  - J Nat Prod
JT  - Journal of natural products
JID - 7906882
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Coumarins)
RN  - 0 (Immunologic Factors)
RN  - 0 (NF-kappa B)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (lepidotol A)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Cell Adhesion/drug effects
MH  - Coumarins/chemistry/*isolation & purification/*pharmacology
MH  - Endothelial Cells/drug effects/*metabolism
MH  - Fruit/chemistry
MH  - Humans
MH  - Immunologic Factors/pharmacology
MH  - Inflammation/metabolism
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Malpighiaceae/*chemistry
MH  - Molecular Structure
MH  - NF-kappa B/metabolism
MH  - Tumor Necrosis Factor-alpha
MH  - Vascular Cell Adhesion Molecule-1
EDAT- 2015/08/25 06:00
MHDA- 2015/12/23 06:00
CRDT- 2015/08/25 06:00
PHST- 2015/08/25 06:00 [entrez]
PHST- 2015/08/25 06:00 [pubmed]
PHST- 2015/12/23 06:00 [medline]
AID - 10.1021/acs.jnatprod.5b00222 [doi]
PST - ppublish
SO  - J Nat Prod. 2015 Sep 25;78(9):2187-97. doi: 10.1021/acs.jnatprod.5b00222. Epub 
      2015 Aug 24.