PMID- 26302731
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150825
LR  - 20201001
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 6
IP  - 2
DP  - 2015 Jan
TI  - Association of IL13R alpha 1 +1398A/G polymorphism in a North Indian population 
      with asthma: A case-control study.
PG  - 111-7
LID - 10.2500/ar.2015.6.0126 [doi]
AB  - BACKGROUND: Interleukin 13 (IL13) is directly involved in the secretion of total 
      serum immunoglobulin E (IgE), which plays a major role in the asthma 
      pathogenesis. OBJECTIVE: One of the polymorphic receptor of IL13 is IL13Ralpha1, 
      which after binding to IL13, initiates signal transduction that results in mucin 
      secretion, airway hyperreactivity, fibrosis, and chitinase up-regulation, which 
      increases asthma risk. METHODS: In the present study, the role of IL13Ralpha1 
      +1398A/G gene polymorphisms in asthma was detected with a total of 964 
      individuals, including 483 healthy controls and 481 asthma patients from a North 
      Indian population using polymerase chain reaction-restriction fragment length 
      polymorphism method. RESULTS: Statistical analysis revealed that the mutant 
      allele (G) is predominant in asthma patients (42.7%) than the controls (38.2%), 
      which shows an increased risk toward asthma with odds ratio = 1.21, 95% 
      confidence interval (1.00-1.45), chi(2) = 4.10 and p = 0.043. Furthermore, the 
      phenotypic characteristics also reveal a significant association with the disease 
      (p < 0.05). CONCLUSIONS: This is the first study conducted in India and +1398A/G 
      polymorphism in noncoding region of IL13Ralpha1 confer risk toward asthma in the 
      studied population.
FAU - Sinha, Shweta
AU  - Sinha S
AD  - Department of Biotechnology, Panjab University, Chandigarh, India.
FAU - Singh, Jagtar
AU  - Singh J
FAU - Jindal, Surinder Kumar
AU  - Jindal SK
FAU - Birbian, Niti
AU  - Birbian N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC4541631
COIS- The authors have no conflicts of interest to declare pertaining to this article
EDAT- 2015/08/26 06:00
MHDA- 2015/08/26 06:01
PMCR- 2015/06/01
CRDT- 2015/08/26 06:00
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2015/08/26 06:01 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - AR074-14 [pii]
AID - 10.2500/ar.2015.6.0126 [doi]
PST - ppublish
SO  - Allergy Rhinol (Providence). 2015 Jan;6(2):111-7. doi: 10.2500/ar.2015.6.0126.