PMID- 26302914 OWN - NLM STAT- MEDLINE DCOM- 20160523 LR - 20150825 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 32 DP - 2015 Oct TI - Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. PG - 66-72 LID - S0946-672X(15)30003-1 [pii] LID - 10.1016/j.jtemb.2015.05.006 [doi] AB - BACKGROUND: Chromium is an essential mineral that contributes to normal glucose function and lipid metabolism. This study evaluated the effect of chromium picolinate (CrPic) supplementation in patients with type 2 diabetes mellitus (T2DM). METHODS: A four month controlled, single blind, randomized trial was performed with 71 patients with poorly controlled (hemoglobin A1c [HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and supplemented (n=32, using 600mug/day CrPic). All patients received nutritional guidance according to the American Diabetes Association (ADA), and kept using prescribed medications. Fasting and postprandial glucose, HbA1c, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides and serum ferritin were evaluated. RESULTS: CrPic supplementation significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group) and postprandial glucose concentration (-37.0mg/dL in the supplemented group; -11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups). Post-treatment HbA1c values in supplemented patients were significantly lower than those of control patients. HbA1c lowering in the supplemented group (-1.90), and in the control group (-1.00), was also significant, comparing pre- and post-treatment values, for each group (p<0.001 and p<0.05, respectively). CrPic increased serum chromium concentrations (p<0.001), when comparing the supplemented group before and after supplementation. No significant difference in lipid profile was observed in the supplemented group; however, total cholesterol, HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment period, in the control group (p<0.05). CONCLUSIONS: CrPic supplementation had a beneficial effect on glycemic control in patients with poorly controlled T2DM, without affecting the lipid profile. Additional studies are necessary to investigate the effect of long-term CrPic supplementation. CI - Copyright (c) 2015 Elsevier GmbH. All rights reserved. FAU - Paiva, Ana N AU - Paiva AN AD - Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petropolis, Natal-RN CEP 59012-570, Brazil. Electronic address: ananpaiva@gmail.com. FAU - Lima, Josivan G de AU - Lima JG AD - Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Pecanha, 620, Petropolis, Natal-RN CEP 59012-300, Brazil. Electronic address: josivanlima@gmail.com. FAU - Medeiros, Anna C Q de AU - Medeiros AC AD - Health Sciences College of Trairi, Federal University of Rio Grande do Norte (UFRN) Rua Trairi, S/N-Centro-Santa Cruz/RN, CEP 59200-000, Brazil. Electronic address: annacqm@yahoo.com.br. FAU - Figueiredo, Heverton A O AU - Figueiredo HA AD - Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: figueiredoheverton@gmail.com. FAU - Andrade, Raiana L de AU - Andrade RL AD - Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: raianalourenco.a@hotmail.com. FAU - Ururahy, Marcela A G AU - Ururahy MA AD - Post Doctoral Fellow in the Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petropolis, Natal-RN CEP 59012-570, Brazil. Electronic address: marcelaururahy@yahoo.com.br. FAU - Rezende, Adriana A AU - Rezende AA AD - Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petropolis, Natal-RN CEP 59012-570, Brazil. Electronic address: adrirezende@yahoo.com. FAU - Brandao-Neto, Jose AU - Brandao-Neto J AD - Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Pecanha, 620, Petropolis, Natal-RN CEP 59012-300, Brazil. Electronic address: brandao-neto@live.com. FAU - Almeida, Maria das G AU - Almeida Md AD - Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petropolis, Natal-RN CEP 59012-570, Brazil. Electronic address: mgalmeida84@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20150528 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - 0 (Picolinic Acids) RN - QZV2W997JQ (picolinic acid) SB - IM MH - Administration, Oral MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/*complications/*drug therapy MH - *Dietary Supplements MH - Female MH - Humans MH - Hyperglycemia/*complications/*drug therapy MH - Male MH - Middle Aged MH - Picolinic Acids/*administration & dosage/*therapeutic use OTO - NOTNLM OT - Chromium picolinate OT - Dietary supplements OT - Dyslipidemia OT - Type 2 diabetes mellitus EDAT- 2015/08/26 06:00 MHDA- 2016/05/24 06:00 CRDT- 2015/08/26 06:00 PHST- 2014/11/10 00:00 [received] PHST- 2015/05/07 00:00 [revised] PHST- 2015/05/26 00:00 [accepted] PHST- 2015/08/26 06:00 [entrez] PHST- 2015/08/26 06:00 [pubmed] PHST- 2016/05/24 06:00 [medline] AID - S0946-672X(15)30003-1 [pii] AID - 10.1016/j.jtemb.2015.05.006 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2015 Oct;32:66-72. doi: 10.1016/j.jtemb.2015.05.006. Epub 2015 May 28.