PMID- 26303198
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20190501
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 6
DP  - 2015 Aug 25
TI  - Learning-related representational changes reveal dissociable integration and 
      separation signatures in the hippocampus and prefrontal cortex.
PG  - 8151
LID - 10.1038/ncomms9151 [doi]
LID - 8151
AB  - The episodic memory system enables accurate retrieval while maintaining 
      flexibility by representing both specific episodes and generalizations across 
      events. Although theories suggest that the hippocampus (HPC) is dedicated to 
      represent specific episodes while the medial prefrontal cortex (MPFC) 
      generalizes, other accounts posit that HPC can also integrate related memories. 
      Here we use high-resolution functional magnetic resonance imaging in humans to 
      examine how representations of memory elements change to either differentiate or 
      generalize across related events. We show that while posterior HPC and anterior 
      MPFC maintain distinct memories for individual events, anterior HPC and posterior 
      MPFC integrate across memories. Integration is particularly likely for 
      established memories versus those encoded simultaneously, highlighting the 
      greater impact of prior knowledge on new encoding. We also show dissociable 
      coding signatures in ventrolateral PFC, a region previously implicated in 
      interference resolution. These data highlight how memory elements are represented 
      to simultaneously promote generalization across memories and protect from 
      interference.
FAU - Schlichting, Margaret L
AU  - Schlichting ML
AD  - Center for Learning and Memory, The University of Texas at Austin, 1 University 
      Station, C7000, Austin, Texas 78712, USA.
AD  - Department of Psychology, The University of Texas at Austin, 1 University 
      Station, A8000, Austin, TX 78712, USA.
FAU - Mumford, Jeanette A
AU  - Mumford JA
AD  - Center for Investigating Healthy Minds at the Waisman Center, University of 
      Wisconsin-Madison, 1500 Highland Avenue, Suite S119, Madison, Wisconsin 
      53705-2280, USA.
FAU - Preston, Alison R
AU  - Preston AR
AD  - Center for Learning and Memory, The University of Texas at Austin, 1 University 
      Station, C7000, Austin, Texas 78712, USA.
AD  - Department of Psychology, The University of Texas at Austin, 1 University 
      Station, A8000, Austin, TX 78712, USA.
AD  - Department of Neuroscience, The University of Texas at Austin, 1 University 
      Station, C0920, Austin, TX 78712, USA.
LA  - eng
GR  - R01 MH100121/MH/NIMH NIH HHS/United States
GR  - R01MH100121/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150825
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Young Adult
PMC - PMC4560815
EDAT- 2015/08/26 06:00
MHDA- 2016/05/10 06:00
PMCR- 2015/09/05
CRDT- 2015/08/26 06:00
PHST- 2015/04/27 00:00 [received]
PHST- 2015/07/24 00:00 [accepted]
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
PHST- 2015/09/05 00:00 [pmc-release]
AID - ncomms9151 [pii]
AID - 10.1038/ncomms9151 [doi]
PST - epublish
SO  - Nat Commun. 2015 Aug 25;6:8151. doi: 10.1038/ncomms9151.