PMID- 26303647
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20181202
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 20
IP  - 4
DP  - 2016 May
TI  - Prevalence of periodontitis in individuals with human leukocyte antigens (HLA) 
      A9, B15, A2, and B5.
PG  - 703-10
LID - 10.1007/s00784-015-1570-9 [doi]
AB  - OBJECTIVE: Human leukocyte antigens (HLA) have been associated with 
      periodontitis. Previous studies revealed HLA-A9 and HLA-B15 as potential 
      susceptibility factors, while HLA-A2 and HLA-B5 might have protective effects. 
      The aim of the study was to verify these associations in a group of HLA-typed 
      blood donors with previously unknown periodontal status. MATERIALS AND METHODS: 
      In four German centers, 140 blood donors with known HLA class I status were 
      enrolled and allocated to the following five groups: HLA-A9 (N = 24), HLA-B15 
      (N = 20), HLA-A2 (N = 30), HLA-B5 (N = 26), and controls (N = 40). Periodontal 
      examination included the measurement of probing depths (PDs), clinical attachment 
      level (CAL), bleeding on probing (BOP), and community periodontal index of 
      treatment needs (CPITN). RESULTS: Carriers with HLA-A9 and HLA-B15 had higher 
      values of mean PD (P < 0.0001), CAL (P < 0.0001), and BOP (P < 0.002) as well as 
      sites with PD and CAL with >/=4 and >/=6 mm (P < 0.0003), respectively, than 
      controls. Multiple regression analyses revealed HLA-A9, HLA-B15, and smoking as 
      risk indicators for moderate to severe (CPITN 3-4; odds ratio (OR): 66.7, 15.3, 
      and 5.1) and severe (CPITN 4; OR: 6.6, 7.4, and 3.8) periodontitis. HLA-A2 and 
      HLA-B5 did not show any relevant associations. CONCLUSION: The present data 
      support a role of HLA-A9 and HLA-B15 as susceptibility factors for periodontitis, 
      whereas HLA-A2 and HLA-B5 could not be confirmed as resistance factors. CLINICAL 
      RELEVANCE: Both HLA antigens A9 and B15 are potential candidates for periodontal 
      risk assessment.
FAU - Stein, Jamal M
AU  - Stein JM
AD  - Department of Operative Dentistry, Periodontology and Preventive Dentistry, 
      University Hospital (RWTH) Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. 
      JStein@ukaachen.de.
FAU - Machulla, Helmut K G
AU  - Machulla HK
AD  - Institute of Physiology, University of the Saarland, Kirrberger Strasse 100, 
      66424, Homburg/Saar, Germany.
FAU - Deschner, James
AU  - Deschner J
AD  - Section of Experimental Dento-Maxillo-Facial Medicine, University of Bonn, 
      Welschnonnenstrasse 17, 53111, Bonn, Germany.
FAU - Fickl, Stefan
AU  - Fickl S
AD  - Department of Periodontology, University Hospital Wurzburg, Pleicherwall 2, 
      97070, Wurzburg, Germany.
FAU - Jockel-Schneider, Yvonne
AU  - Jockel-Schneider Y
AD  - Department of Periodontology, University Hospital Wurzburg, Pleicherwall 2, 
      97070, Wurzburg, Germany.
FAU - Tamm, Miriam
AU  - Tamm M
AD  - Department of Medical Statistics, University Hospital (RWTH) Aachen, 
      Pauwelsstrasse 30, 52074, Aachen, Germany.
FAU - Schulz, Susanne
AU  - Schulz S
AD  - Department of Operative Dentistry and Periodontology, Martin Luther University 
      Halle-Wittenberg, Grosse Steinstrasse 19, 06108, Halle (Saale), Germany.
FAU - Reichert, Stefan
AU  - Reichert S
AD  - Department of Operative Dentistry and Periodontology, Martin Luther University 
      Halle-Wittenberg, Grosse Steinstrasse 19, 06108, Halle (Saale), Germany.
LA  - eng
PT  - Journal Article
DEP - 20150826
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (HLA Antigens)
MH  - *HLA Antigens
MH  - Humans
MH  - Periodontal Index
MH  - Periodontitis/*epidemiology/immunology
MH  - Prevalence
OTO - NOTNLM
OT  - HLA
OT  - Major histocompatibility complex
OT  - Periodontitis
OT  - Risk factors
EDAT- 2015/08/26 06:00
MHDA- 2018/06/23 06:00
CRDT- 2015/08/26 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/08/16 00:00 [accepted]
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
AID - 10.1007/s00784-015-1570-9 [pii]
AID - 10.1007/s00784-015-1570-9 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2016 May;20(4):703-10. doi: 10.1007/s00784-015-1570-9. Epub 
      2015 Aug 26.