PMID- 26304470
OWN - NLM
STAT- MEDLINE
DCOM- 20160831
LR  - 20151014
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 43
IP  - 11
DP  - 2015 Nov
TI  - Fine needle aspiration of secondary synovial sarcoma of the thyroid gland.
PG  - 928-32
LID - 10.1002/dc.23327 [doi]
AB  - Synovial sarcomas (SS) of the head and neck region are extremely rare and arise 
      in only 5% of cases. We present a case of secondary SS of the thyroid originally 
      diagnosed as medullary carcinoma on fine needle aspiration (FNA). A 41-year-old 
      man presented with several weeks of dysphonia and a left thyroid mass. FNA of the 
      thyroid nodule showed a cellular smear composed of loosely cohesive oval to 
      spindle-shaped cells with irregular nuclear borders, finely granular chromatin, 
      and inconspicuous nucleoli. The patient was diagnosed with medullary carcinoma 
      and underwent a total thyroidectomy. Intro-operatively, the mass was found to 
      arise from the tracheoesophageal groove with spread to the left thyroid. 
      Microscopic examination of the thyroid tumor revealed a dense spindle cell 
      proliferation with abundant mitoses, scant cords and nests of epithelial cells 
      and foci of necrosis. The spindle cells were positive for bcl2 and vimentin and 
      the epithelial cells were positive for cytokeratin 8/18 and epithelial membrane 
      antigen (EMA). Both spindle and epithelial cells were negative for thyroglobulin, 
      calcitonin, synaptophysin and chromogranin. Fluorescence in situ hybridization 
      (FISH) demonstrated translocation (X;18)(p11;q11), confirming the diagnosis of 
      SS. The patient underwent a total laryngopharyngoesophagectomy with subsequent 
      adjuvant therapy and is currently disease free. Only 6 cases of histologically 
      confirmed primary SS of the thyroid have been reported. To the best of our 
      knowledge, this is the first case of FISH-confirmed secondary SS of the thyroid 
      and also the first case of SS arising from the tracheoesophageal groove.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Murro, Diana
AU  - Murro D
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Slade, Jamie Macagba
AU  - Slade JM
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Syed, Sahr
AU  - Syed S
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
FAU - Gattuso, Paolo
AU  - Gattuso P
AD  - Department of Pathology, Rush University Medical Center, Chicago, Illinois.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150825
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Biomarkers, Tumor)
RN  - Thyroid cancer, medullary
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/analysis
MH  - *Biopsy, Fine-Needle/methods
MH  - Carcinoma, Medullary/diagnosis/pathology
MH  - Carcinoma, Neuroendocrine/diagnosis/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Sarcoma, Synovial/diagnosis/*pathology/*secondary
MH  - Thyroid Gland/*pathology
MH  - Thyroid Neoplasms/diagnosis/pathology
MH  - Thyroid Nodule/*pathology
OTO - NOTNLM
OT  - fine needle aspiration
OT  - medullary thyroid carcinoma
OT  - secondary thyroid malignancies
OT  - synovial sarcoma
OT  - tracheoesophageal
EDAT- 2015/08/26 06:00
MHDA- 2016/09/01 06:00
CRDT- 2015/08/26 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/06/24 00:00 [revised]
PHST- 2015/08/05 00:00 [accepted]
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2016/09/01 06:00 [medline]
AID - 10.1002/dc.23327 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2015 Nov;43(11):928-32. doi: 10.1002/dc.23327. Epub 2015 Aug 
      25.