PMID- 26305170
OWN - NLM
STAT- MEDLINE
DCOM- 20160713
LR  - 20150909
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 7
IP  - 35
DP  - 2015 Sep 9
TI  - Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics.
PG  - 19709-17
LID - 10.1021/acsami.5b05180 [doi]
AB  - Although enzyme-like nanomaterials have been extensively investigated over the 
      past decade, most research has focused on the peroxidase-like, catalase-like, or 
      SOD-like activity of these nanomaterials. Identifying nanomaterials having 
      oxidase-like activities has received less attention. In this study, we 
      demonstrate that platinum nanoparticles (Pt NPs) exhibit catechol oxidase-like 
      activity, oxidizing polyphenols into the corresponding o-quinones. Four unique 
      approaches are employed to demonstrate the catechol oxidase-like activity exerted 
      by Pt NPs. First, UV-vis spectroscopy is used to monitor the oxidation of 
      polyphenols catalyzed by Pt NPs. Second, the oxidized products of polyphenols are 
      identified by ultrahigh-performance liquid chromatography (UHPLC) separation 
      followed by high-resolution mass spectrometry (HRMS) identification. Third, 
      electron spin resonance (ESR) oximetry techniques are used to confirm the O2 
      consumption during the oxidation reaction. Fourth, the intermediate products of 
      semiquinone radicals formed during the oxidation of polyphenols are determined by 
      ESR using spin stabilization. These results indicate Pt NPs possess catechol 
      oxidase-like activity. Because polyphenols and related bioactive substances have 
      been explored as potent antioxidants that could be useful for the prevention of 
      cancer and cardiovascular diseases, and Pt NPs have been widely used in the 
      chemical industry and medical science, it is essential to understand the 
      potential effects of Pt NPs for altering or influencing the antioxidant activity 
      of polyphenols.
FAU - Liu, Yi
AU  - Liu Y
AD  - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food 
      Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, 
      Maryland 20740, United States.
AD  - Department of Chemistry and Biochemistry, University of Maryland , College Park, 
      Maryland 20742, United States.
FAU - Wu, Haohao
AU  - Wu H
AD  - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food 
      Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, 
      Maryland 20740, United States.
FAU - Chong, Yu
AU  - Chong Y
AD  - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food 
      Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, 
      Maryland 20740, United States.
FAU - Wamer, Wayne G
AU  - Wamer WG
AD  - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for 
      Food Safety and Applied Nutrition, U.S. Food and Drug Administration , College 
      Park, Maryland 20740, United States.
FAU - Xia, Qingsu
AU  - Xia Q
AD  - Biochemical Toxicology Division, National Center for Toxicological Research, U.S. 
      Food and Drug Administration , Jefferson, Arkansas 72079, United States.
FAU - Cai, Lining
AU  - Cai L
AD  - Biotranex LLC , Monmouth Junction, New Jersey 08852, United States.
FAU - Nie, Zhihong
AU  - Nie Z
AD  - Department of Chemistry and Biochemistry, University of Maryland , College Park, 
      Maryland 20742, United States.
FAU - Fu, Peter P
AU  - Fu PP
AD  - Biochemical Toxicology Division, National Center for Toxicological Research, U.S. 
      Food and Drug Administration , Jefferson, Arkansas 72079, United States.
FAU - Yin, Jun-Jie
AU  - Yin JJ
AD  - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food 
      Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, 
      Maryland 20740, United States.
LA  - eng
GR  - 5U01FD001418/FD/FDA HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20150828
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Caffeic Acids)
RN  - 0 (Polyphenols)
RN  - 0 (Quinones)
RN  - 49DFR088MY (Platinum)
RN  - 8R1V1STN48 (Catechin)
RN  - 9IKM0I5T1E (Quercetin)
RN  - EC 1.10.3.1 (Catechol Oxidase)
RN  - EC 1.14.18.1 (Monophenol Monooxygenase)
RN  - S88TT14065 (Oxygen)
RN  - U2S3A33KVM (caffeic acid)
SB  - IM
MH  - Biomimetic Materials/*chemistry/metabolism
MH  - Caffeic Acids/chemistry
MH  - Catalysis
MH  - Catechin/chemistry
MH  - Catechol Oxidase/chemistry/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Electron Spin Resonance Spectroscopy
MH  - Mass Spectrometry
MH  - Metal Nanoparticles/*chemistry
MH  - Monophenol Monooxygenase/chemistry/metabolism
MH  - Oxidation-Reduction
MH  - Oxygen/chemistry
MH  - Platinum/*chemistry
MH  - Polyphenols/analysis/chemistry
MH  - Quercetin/chemistry
MH  - Quinones/analysis/chemistry
OTO - NOTNLM
OT  - catechol oxidase-like activity
OT  - enzyme mimetics
OT  - heterogeneous catalysts
OT  - oxidation of polyphenols
OT  - platinum nanoparticles
EDAT- 2015/08/26 06:00
MHDA- 2016/07/14 06:00
CRDT- 2015/08/26 06:00
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2016/07/14 06:00 [medline]
AID - 10.1021/acsami.5b05180 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2015 Sep 9;7(35):19709-17. doi: 
      10.1021/acsami.5b05180. Epub 2015 Aug 28.