PMID- 26305337
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 8
DP  - 2015
TI  - Study of Five Pubertal Transition-Related Gene Polymorphisms as Risk Factors for 
      Premature Coronary Artery Disease in a Chinese Han Population.
PG  - e0136496
LID - 10.1371/journal.pone.0136496 [doi]
LID - e0136496
AB  - BACKGROUND: Recently, single nucleotide polymorphisms (SNPs) (DLK-rs10144321, 
      SIX6-rs1254337, MKRN3-rs12148769, LIN28B-rs7759938, and KCNK9-rs1469039) were 
      found to be strongly associated with age at menarche. Recent studies also 
      suggested that age at menarche is a heritable trait and is associated with risks 
      for obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and 
      all-cause mortality. Since an association between these five SNPs and premature 
      coronary artery disease (CAD) has never been reported, we investigated whether 
      these SNPs are associated with premature CAD and its severity in a Chinese Han 
      population. METHODS: We enrolled 432 consecutive patients including 198 with 
      premature CAD (<55 years in men and <65 years in women) and 234 controls. All 
      subjects were genotyped for the five SNPs by the PCR-ligase detection reaction 
      method. The associations between these SNPs and premature CAD and its severity 
      were analyzed. RESULTS: The following genotypes were identified: GG, AG, and AA 
      at rs10144321 and rs12148769; TT, AT, and AA at rs1254337; CC, CT, and TT at 
      rs1469039; and TT and CT at rs7759938. Significant differences in genotype 
      distribution frequencies at rs1254337 were found between controls and patients 
      with premature CAD (P<0.05). No associations were found between the five SNPs and 
      the severity of coronary lesions (all P>0.05). Compared with controls, patients 
      with premature CAD had a higher prevalence of T2DM and dyslipidemia, and the 
      proportion of patients with T2DM rose significantly with an increase in the 
      number of stenosed coronary vessels (all P<0.05). After adjustment for the 
      clinical parameters in multivariable analysis, three factors were identified that 
      significantly increased the risk of premature CAD: the AA genotype at rs1254337 
      (OR: 2.388, 95% CI: 1.190-4.792, P = 0.014), male gender (OR: 1.565, 95% CI: 
      1.012-2.420, P = 0.044), and T2DM (OR 2.252, 95% CI: 1.233-4.348, P = 0.015). 
      CONCLUSIONS: Among the five pubertal transition-related gene polymorphisms, we 
      identified an association between rs1254337 and premature CAD in a Chinese Han 
      population.
FAU - Chen, Bin
AU  - Chen B
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, No. 600 Yishan Road, Shanghai 200233, China.
FAU - Xie, Fangyi
AU  - Xie F
AD  - Central Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, No. 600 Yishan Road, Shanghai 200233, China.
FAU - Tang, Chengchun
AU  - Tang C
AD  - Department of Cardiology, The Affiliated Zhongda Hospital of Southeast 
      University, No. 87 Dingjiaqiao, Nanjing 210009, China.
FAU - Ma, Genshan
AU  - Ma G
AD  - Department of Cardiology, The Affiliated Zhongda Hospital of Southeast 
      University, No. 87 Dingjiaqiao, Nanjing 210009, China.
FAU - Wei, Li
AU  - Wei L
AD  - Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth 
      People's Hospital, No. 600 Yishan Road, Shanghai 200233, China.
FAU - Chen, Zhong
AU  - Chen Z
AD  - Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's 
      Hospital, No. 600 Yishan Road, Shanghai 200233, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150825
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Coronary Artery Disease/*genetics
MH  - Ethnicity/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Puberty/*genetics
MH  - Risk Factors
PMC - PMC4549330
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/08/26 06:00
MHDA- 2016/05/18 06:00
PMCR- 2015/08/25
CRDT- 2015/08/26 06:00
PHST- 2015/04/16 00:00 [received]
PHST- 2015/08/04 00:00 [accepted]
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2015/08/25 00:00 [pmc-release]
AID - PONE-D-15-14632 [pii]
AID - 10.1371/journal.pone.0136496 [doi]
PST - epublish
SO  - PLoS One. 2015 Aug 25;10(8):e0136496. doi: 10.1371/journal.pone.0136496. 
      eCollection 2015.