PMID- 26305405
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20150912
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 184
IP  - 3
DP  - 2015 Sep
TI  - Chromosome Aberrations Determined by FISH in Radiation Workers from the 
      Sellafield Nuclear Facility.
PG  - 296-303
LID - 10.1667/RR14125.1 [doi]
AB  - Workers from the Sellafield nuclear facility (Cumbria, UK) with occupational 
      exposures to external sources of ionizing radiation were examined for 
      translocation frequencies in peripheral blood lymphocytes using fluorescence in 
      situ hybridization (FISH). This is an extension of an earlier study of retired 
      workers, and includes analyses of additional samples from the earlier collection, 
      bringing the total to 321. Another 164 samples from both current and retired 
      employees, including 26 repeat samples, were obtained from a new collection, thus 
      giving a combined dataset of 459 workers. This all-male population of workers was 
      divided into 6 dose groups comprising 97 with recorded external occupational 
      doses <50 mGy, 118 with 50-249 mGy, 129 with 250-499 mGy, 89 with 500-749 mGy, 17 
      with 750-999 mGy and 9 with >1,000 mGy. Univariate analysis showed a significant 
      association between external dose and translocation frequency (P < 0.001) with 
      the estimate of slope +/- standard error being 1.174 +/- 0.164 x 10(-2) 
      translocations per Gy. Multivariate analysis revealed that age increased the rate 
      of translocations by 0.0229 +/- 0.0052 x 10(-2) per year (P < 0.001). However, the 
      impact of age adjustment on the radiation dose response for translocation 
      frequencies was minor with the new estimate of slope +/- standard error being 1.163 
      +/- 0.162 x 10(-2) translocations per Gy. With the dose response for the induction 
      of translocations by chronic in vivo low-LET radiation now well characterized, 
      cytogenetic analysis can play an integral role in retrospective dose 
      reconstruction of chronic exposure in epidemiological studies of exposed 
      populations.
FAU - Tawn, E Janet
AU  - Tawn EJ
AD  - a  Centre for Integrated Genomic Medical Research (CIGMR), Centre for 
      Epidemiology, Institute of Population Health, The University of Manchester, 
      Manchester, M13 9PT, United Kingdom.
AD  - b  Formerly of Westlakes Research Institute2, Westlakes Science and Technology 
      Park, Moor Row, Cumbria, CA24 3LN, United Kingdom.
FAU - Curwen, Gillian B
AU  - Curwen GB
AD  - a  Centre for Integrated Genomic Medical Research (CIGMR), Centre for 
      Epidemiology, Institute of Population Health, The University of Manchester, 
      Manchester, M13 9PT, United Kingdom.
AD  - b  Formerly of Westlakes Research Institute2, Westlakes Science and Technology 
      Park, Moor Row, Cumbria, CA24 3LN, United Kingdom.
FAU - Jonas, Patricia
AU  - Jonas P
AD  - c  Formerly of Northern Genetics Service, Institute of Genetic Medicine, 
      International Centre for Life, Newcastle University, Newcastle upon Tyne, NE1 
      3BZ, United Kingdom.
FAU - Gillies, Michael
AU  - Gillies M
AD  - b  Formerly of Westlakes Research Institute2, Westlakes Science and Technology 
      Park, Moor Row, Cumbria, CA24 3LN, United Kingdom.
AD  - d  Public Health England, Centre for Radiation, Chemical and Environmental 
      Hazards, Westlakes Science and Technology Park, Moor Row, Cumbria, CA24 3HU, 
      United Kingdom.
FAU - Hodgson, Leanne
AU  - Hodgson L
AD  - b  Formerly of Westlakes Research Institute2, Westlakes Science and Technology 
      Park, Moor Row, Cumbria, CA24 3LN, United Kingdom.
FAU - Cadwell, Kevin K
AU  - Cadwell KK
AD  - b  Formerly of Westlakes Research Institute2, Westlakes Science and Technology 
      Park, Moor Row, Cumbria, CA24 3LN, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150825
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - *Chromosome Aberrations
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Occupational Exposure/*analysis
EDAT- 2015/08/26 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/08/26 06:00
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1667/RR14125.1 [doi]
PST - ppublish
SO  - Radiat Res. 2015 Sep;184(3):296-303. doi: 10.1667/RR14125.1. Epub 2015 Aug 25.