PMID- 26305727
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 19
IP  - 1
DP  - 2016 Jan
TI  - Topical Application of Angelica sinensis Improves Pruritus and Skin Inflammation 
      in Mice with Atopic Dermatitis-Like Symptoms.
PG  - 98-105
LID - 10.1089/jmf.2015.3489 [doi]
AB  - Angelica sinensis (AS) is one of the most popular medicinal foods used as a 
      hematopoietic herb and also traditionally applied topically for skin disorders. 
      However, the effectiveness of AS on atopic dermatitis (AD) has not been reported 
      yet. This study was conducted to evaluate the antipruritic and anti-inflammatory 
      effects of AS on regulating AD-related mediators in DNCB 
      (2,4-dinitrochlorobenzene)-induced mice. AS was topically applied to the dorsal 
      skin of DNCB-challenged mice for 11 days. Alteration of skin thickness was 
      measured for assessment of histological improvement. In addition, the number of 
      mast cells, the level of serum immunoglobulin E (IgE), the counting of scratching 
      behavior, and the expression of substance P were evaluated. Also, the expressions 
      of cytokines, nuclear factor kappaB (NF-kappaB), phospho-IkappaBalpha, and mitogen-activated 
      protein kinases (MAPKs) were measured for evaluating the improvement of skin 
      inflammation. The repeated treatment of AS significantly inhibited the skin 
      thickness, the number of mast cells, and the level of serum IgE. Moreover, AS 
      significantly suppressed the increased scratching behavior and the expression of 
      substance P compared to the DNCB group. Topical application of AS also reduced 
      the level of cytokines (IL-4, IL-6, TNF-alpha, and IFN-gamma) as well as the expressions 
      of NF-kappaB, phospho-IkappaBalpha, and phospho-MAPKs in the dorsal skin. The results of our 
      study suggest that topical application of AS might have efficacy for modulating 
      pruritus and inflammation in AD. Further studies are required to further 
      characterize the mechanism of actions of AS.
FAU - Lee, Jaehong
AU  - Lee J
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
FAU - Choi, You Yeon
AU  - Choi YY
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
FAU - Kim, Mi Hye
AU  - Kim MH
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
FAU - Han, Jae Min
AU  - Han JM
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
FAU - Lee, Ji Eun
AU  - Lee JE
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
FAU - Kim, Eun Hye
AU  - Kim EH
AD  - 2 College of Pharmacy, Kyung Hee University , Seoul, Republic of Korea.
FAU - Hong, Jongki
AU  - Hong J
AD  - 2 College of Pharmacy, Kyung Hee University , Seoul, Republic of Korea.
FAU - Kim, Jinju
AU  - Kim J
AD  - 3 Department of Oriental Physiology, College of Pharmacy, Kyung Hee University , 
      Seoul, Republic of Korea.
FAU - Yang, Woong Mo
AU  - Yang WM
AD  - 1 Department of Convergence Korean Medical Science, College of Korean Medicine 
      and Institute of Korean Medicine, Kyung Hee University , Seoul, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150825
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Angelica sinensis/*chemistry
MH  - Animals
MH  - Dermatitis, Atopic/*drug therapy/genetics/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/genetics/immunology
MH  - Interleukin-4/genetics/immunology
MH  - Interleukin-6/genetics/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/genetics/immunology
MH  - Plant Extracts/*administration & dosage
MH  - Pruritus/*drug therapy/genetics/*immunology
MH  - Skin/drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
OTO - NOTNLM
OT  - Angelica sinensis
OT  - anti-inflammation
OT  - atopic dermatitis
OT  - pruritus
EDAT- 2015/08/26 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/08/26 06:00
PHST- 2015/08/26 06:00 [entrez]
PHST- 2015/08/26 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.1089/jmf.2015.3489 [doi]
PST - ppublish
SO  - J Med Food. 2016 Jan;19(1):98-105. doi: 10.1089/jmf.2015.3489. Epub 2015 Aug 25.