PMID- 26308143
OWN - NLM
STAT- MEDLINE
DCOM- 20160512
LR  - 20191210
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 140
IP  - 21
DP  - 2015 Nov 7
TI  - Bioanalytical and chemical sensors using living taste, olfactory, and neural 
      cells and tissues: a short review.
PG  - 7048-61
LID - 10.1039/c5an01288k [doi]
AB  - Biosensors utilizing living tissues and cells have recently gained significant 
      attention as functional devices for chemical sensing and biochemical analysis. 
      These devices integrate biological components (i.e. single cells, cell networks, 
      tissues) with micro-electro-mechanical systems (MEMS)-based sensors and 
      transducers. Various types of cells and tissues derived from natural and 
      bioengineered sources have been used as recognition and sensing elements, which 
      are generally characterized by high sensitivity and specificity. This review 
      summarizes the state of the art in tissue- and cell-based biosensing platforms 
      with an emphasis on those using taste, olfactory, and neural cells and tissues. 
      Many of these devices employ unique integration strategies and sensing schemes 
      based on sensitive transducers including microelectrode arrays (MEAs), field 
      effect transistors (FETs), and light-addressable potentiometric sensors (LAPSs). 
      Several groups have coupled these hybrid biosensors with microfluidics which 
      offers added benefits of small sample volumes and enhanced automation. While this 
      technology is currently limited to lab settings due to the limited stability of 
      living biological components, further research to enhance their robustness will 
      enable these devices to be employed in field and clinical settings.
FAU - Wu, Chunsheng
AU  - Wu C
AD  - Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering 
      of Ministry of Education, Department of Biomedical Engineering, Zhejiang 
      University, Hangzhou 310027, China. cnpwang@zju.edu.cn.
FAU - Lillehoj, Peter B
AU  - Lillehoj PB
FAU - Wang, Ping
AU  - Wang P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
SB  - IM
MH  - Animals
MH  - Bioengineering/instrumentation/methods
MH  - Biosensing Techniques/instrumentation
MH  - Humans
MH  - Light
MH  - *Micro-Electrical-Mechanical Systems
MH  - Microfluidics/instrumentation
MH  - Neural Networks, Computer
MH  - Neurons/*metabolism
MH  - Potentiometry/instrumentation/methods
MH  - Reproducibility of Results
MH  - Semiconductors
MH  - *Smell
MH  - *Taste
MH  - Temperature
MH  - Transducers
EDAT- 2015/08/27 06:00
MHDA- 2016/05/14 06:00
CRDT- 2015/08/27 06:00
PHST- 2015/08/27 06:00 [entrez]
PHST- 2015/08/27 06:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
AID - 10.1039/c5an01288k [doi]
PST - ppublish
SO  - Analyst. 2015 Nov 7;140(21):7048-61. doi: 10.1039/c5an01288k.