PMID- 26308599
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181113
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 35
IP  - 12
DP  - 2015 Dec
TI  - Decreased Interferon Alpha/Beta Signature Associated with Human Lung 
      Tumorigenesis.
PG  - 963-8
LID - 10.1089/jir.2015.0061 [doi]
AB  - Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in 
      antitumor immunity and cancer immunoediting, but information on the antitumor 
      effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated 
      the IFN alpha/beta signature during both human fetal lung development and lung 
      tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta 
      signature during human fetal lung development. In addition, this signature was 
      progressively downregulated in normal human airway epithelial cells from lung 
      cancer patients, in immortalized human bronchial epithelial cell lines from later 
      passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC 
      tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, 
      lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. 
      This association may provide insight to guide the detection of high-risk lung 
      cancer patients.
FAU - Tong, Run
AU  - Tong R
AD  - 1 State Key Laboratory of Molecular Oncology, Department of Etiology and 
      Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and 
      Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Feng, Lin
AU  - Feng L
AD  - 1 State Key Laboratory of Molecular Oncology, Department of Etiology and 
      Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and 
      Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Zhang, Lei
AU  - Zhang L
AD  - 2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical 
      College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Zhang, Jianzhi
AU  - Zhang J
AD  - 3 Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education), Department of Thoracic Surgery, Peking University School of Oncology 
      , Beijing Cancer Hospital & Institute, Beijing, P.R. China .
FAU - Mao, Yousheng
AU  - Mao Y
AD  - 4 Department of Thoracic Surgery, Cancer Hospital and Institute , Peking Union 
      Medical College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Zhang, Kaitai
AU  - Zhang K
AD  - 1 State Key Laboratory of Molecular Oncology, Department of Etiology and 
      Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and 
      Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Gao, Yanning
AU  - Gao Y
AD  - 1 State Key Laboratory of Molecular Oncology, Department of Etiology and 
      Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and 
      Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Wang, Guiqi
AU  - Wang G
AD  - 2 Department of Endoscopy, Cancer Hospital and Institute , Peking Union Medical 
      College, and Chinese Academy of Medical Sciences, Beijing, P.R. China .
FAU - Cheng, Shujun
AU  - Cheng S
AD  - 1 State Key Laboratory of Molecular Oncology, Department of Etiology and 
      Carcinogenesis, Cancer Hospital and Institute , Peking Union Medical College, and 
      Chinese Academy of Medical Sciences, Beijing, P.R. China .
LA  - eng
SI  - GEO/GSE67061
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150826
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Interferon-alpha)
RN  - 77238-31-4 (Interferon-beta)
SB  - IM
MH  - Cell Line
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Computational Biology/methods
MH  - Datasets as Topic
MH  - Down-Regulation
MH  - Epithelial Cells/drug effects/metabolism
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Developmental
MH  - Gene Expression Regulation, Neoplastic/*drug effects
MH  - Humans
MH  - Interferon-alpha/*pharmacology
MH  - Interferon-beta/*pharmacology
MH  - Lung Neoplasms/*genetics/pathology
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Respiratory Mucosa/drug effects/metabolism
PMC - PMC4683557
EDAT- 2015/08/27 06:00
MHDA- 2016/10/08 06:00
PMCR- 2016/12/01
CRDT- 2015/08/27 06:00
PHST- 2015/08/27 06:00 [entrez]
PHST- 2015/08/27 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1089/jir.2015.0061 [pii]
AID - 10.1089/jir.2015.0061 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2015 Dec;35(12):963-8. doi: 10.1089/jir.2015.0061. 
      Epub 2015 Aug 26.