PMID- 26309565
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150828
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - miR-206 inhibits non small cell lung cancer cell proliferation and invasion by 
      targeting SOX9.
PG  - 9107-13
AB  - BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNAs that have 
      been suggested to play an essential role in tumorigenesis. miR-206 functions as a 
      tumor suppressor in several cancers. However, its role in non small cell lung 
      cancer (NSCLC) remains unclear. METHODS: Expression levels of miR-206 in NSCLC 
      tissues and cell lines were determined by quantitative real-time PCR (qRT-PCR). 
      Then, we investigated the role of miR-206 on NSCLC cell proliferation, migration 
      and invasion. Furthermore, luciferase reporter assay was performed to confirm the 
      target gene of miR-206 and the results were validated in NSCLC cells. RESULTS: In 
      the present study, our results showed that miR-206 was decreased in NSCLC tissues 
      compared with adjacent non-tumor tissues. Forced overexpression of miR-206 
      significantly inhibited cell proliferation, migration and invasion of NSCLC 
      cells. SOX9 was found to be a target of miR-206. Furthermore, down-regulation of 
      SOX9 by shRNA performed similar effects with overexpression of miR-206. 
      CONCLUSIONS: Our study suggested that miR-206 acts as tumor suppressor in NSCLC 
      partially via targeting SOX9.
FAU - Zhang, Ya-Jun
AU  - Zhang YJ
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
FAU - Xu, Feng
AU  - Xu F
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
FAU - Zhang, Yi-Jie
AU  - Zhang YJ
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
FAU - Li, Hong-Bing
AU  - Li HB
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
FAU - Han, Ji-Chang
AU  - Han JC
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
FAU - Li, Lei
AU  - Li L
AD  - Department of Respiration Medicine, Huaihe Hospital of Henan University Kaifeng 
      475000, Henan Province, China.
LA  - eng
PT  - Journal Article
DEP - 20150615
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4538070
OTO - NOTNLM
OT  - Non small cell lung cancer
OT  - SOX9
OT  - invasion
OT  - miR-206
OT  - proliferation
EDAT- 2015/08/27 06:00
MHDA- 2015/08/27 06:01
PMCR- 2015/06/15
CRDT- 2015/08/27 06:00
PHST- 2015/03/26 00:00 [received]
PHST- 2015/06/04 00:00 [accepted]
PHST- 2015/08/27 06:00 [entrez]
PHST- 2015/08/27 06:00 [pubmed]
PHST- 2015/08/27 06:01 [medline]
PHST- 2015/06/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Jun 15;8(6):9107-13. eCollection 2015.