PMID- 26309608
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150828
LR  - 20200930
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 6
DP  - 2015
TI  - Auxiliary diagnostic value of monocyte chemoattractant protein-1 of whole blood 
      in active tuberculosis.
PG  - 9454-61
AB  - The aim of this study was to study the expression level of interferon-gamma (IFN-gamma) 
      and monocyte chemoattractant protein-1 (MCP-1) in peripheral blood and its 
      auxiliary diagnostic value in active tuberculosis. A chemiluminescence enzyme 
      immunoassay method was used to detect the levels of IFN-gamma and MCP-1 in peripheral 
      blood. Then the receiver operating characteristic curve were drawn to determine 
      the threshold of IFN-gamma and MCP-1 for diagnosis of active tuberculosis and to 
      evaluate their diagnostic performance. The specific IFN-gamma and MCP-1 levels in the 
      active tuberculosis group were significantly higher than those in the 
      non-tuberculous pulmonary disease group (P < 0.01) and those in the healthy 
      control group (P < 0.01). The IFN-gamma levels in the healthy control group and the 
      non-tuberculous respiratory disease group showed no statistically significant 
      difference (P > 0.05), but the MCP-1 levels in the non-tuberculous respiratory 
      disease group were significantly higher than those of the healthy control group 
      (P < 0.05). The specific IFN-gamma and MCP-1 level cut off values were 256 pg/ml and 
      389 pg/ml as an active tuberculosis diagnostic standard. The sensitivities of 
      IFN-gamma and MCP-1 were 57.3% and 92.8%, respectively; specificities were 80% and 
      80.7%, respectively; the positive predictive values were 76.9% and 84.9%, 
      respectively; negative predictive values were 61.7% and 78.7%, respectively; and 
      accuracy rates were 76.9% and 84.9%, respectively. Compared with the detection of 
      IFN-gamma, we observed a better diagnostic performance of MCP-1 in peripheral blood 
      in active tuberculosis. MCP-1 may become one of the active tuberculosis auxiliary 
      diagnostic targets.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Laboratory, The Second Hospital of Jilin University Changchun 
      130041, China.
FAU - Li, Hang
AU  - Li H
AD  - Department of Thoracic Surgery, The Tumor Hospital of Jilin Province Changchun 
      130021, China.
FAU - Bao, Hong
AU  - Bao H
AD  - Department of Laboratory, The Second Hospital of Jilin University Changchun 
      130041, China.
FAU - Jin, Yufen
AU  - Jin Y
AD  - Department of Laboratory, The Second Hospital of Jilin University Changchun 
      130041, China.
FAU - Liu, Xiaoju
AU  - Liu X
AD  - Department of Laboratory, The Second Hospital of Jilin University Changchun 
      130041, China.
FAU - Wu, Xueqiong
AU  - Wu X
AD  - Department of Tuberculosis Research Laboratory, The 309th Hospital of PLA Beijing 
      100091, China.
FAU - Yu, Ting
AU  - Yu T
AD  - Department of Laboratory, The Second Hospital of Jilin University Changchun 
      130041, China.
LA  - eng
PT  - Journal Article
DEP - 20150615
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4537985
OTO - NOTNLM
OT  - IFN-gamma
OT  - Tuberculosis
OT  - diagnosis
OT  - monocyte chemoattractant protein-1
EDAT- 2015/08/27 06:00
MHDA- 2015/08/27 06:01
PMCR- 2015/06/15
CRDT- 2015/08/27 06:00
PHST- 2015/01/07 00:00 [received]
PHST- 2015/03/31 00:00 [accepted]
PHST- 2015/08/27 06:00 [entrez]
PHST- 2015/08/27 06:00 [pubmed]
PHST- 2015/08/27 06:01 [medline]
PHST- 2015/06/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Jun 15;8(6):9454-61. eCollection 2015.