PMID- 26309783
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150828
LR  - 20201001
IS  - 2164-7844 (Print)
IS  - 2164-7860 (Electronic)
IS  - 2164-7844 (Linking)
VI  - 4
IP  - 1
DP  - 2015
TI  - Treating Proximal Tibial Growth Plate Injuries Using Poly(Lactic-co-Glycolic 
      Acid) Scaffolds.
PG  - 65-74
LID - 10.1089/biores.2014.0034 [doi]
AB  - Growth plate fractures account for nearly 18.5% of fractures in children. 
      Depending on the type and severity of the injury, inhibited bone growth or 
      angular deformity caused by bone forming in place of the growth plate can occur. 
      The current treatment involves removal of the bony bar and replacing it with a 
      filler substance, such as a free fat graft. Unfortunately, reformation of the 
      bony bar frequently occurs, preventing the native growth plate from regenerating. 
      The goal of this pilot study was to determine whether biodegradable scaffolds can 
      enhance native growth plate regeneration following a simulated injury that 
      resulted in bony bar formation in the proximal tibial growth plate of New Zealand 
      white rabbits. After removing the bony bar, animals received one of the following 
      treatments: porous poly(lactic-co-glycolic acid) (PLGA) scaffold; PLGA scaffold 
      loaded with insulin-like growth factor I (IGF-I); PLGA scaffold loaded with IGF-I 
      and seeded with autogenous bone marrow cells (BMCs) harvested at the time of 
      implantation; or fat graft (as used clinically). The PLGA scaffold group showed 
      an increased chondrocyte population and a reduced loss of the remaining native 
      growth plate compared to the fat graft group (the control group). An additional 
      increase in chondrocyte density was seen in scaffolds loaded with IGF-I, and even 
      more so when BMCs were seeded on the scaffold. While there was no significant 
      reduction in the angular deformation of the limbs, the PLGA scaffolds increased 
      the amount of cartilage and reduced the amount of bony bar reformation.
FAU - Clark, Amanda
AU  - Clark A
AD  - Department of Biomedical Engineering, University of Kentucky , Lexington, 
      Kentucky.
FAU - Hilt, J Zach
AU  - Hilt JZ
AD  - Department of Chemical and Materials Engineering, University of Kentucky , 
      Lexington, Kentucky.
FAU - Milbrandt, Todd A
AU  - Milbrandt TA
AD  - Department of Orthopedic Surgery, Mayo Clinic , Rochester, Minnesota.
FAU - Puleo, David A
AU  - Puleo DA
AD  - Department of Biomedical Engineering, University of Kentucky , Lexington, 
      Kentucky.
LA  - eng
PT  - Journal Article
DEP - 20150101
PL  - United States
TA  - Biores Open Access
JT  - BioResearch open access
JID - 101579333
PMC - PMC4497685
OTO - NOTNLM
OT  - growth plate
OT  - insulin-like growth factor I
OT  - physeal injury
OT  - poly(lactic-co-glycolic acid)
OT  - scaffold
EDAT- 2015/08/27 06:00
MHDA- 2015/08/27 06:01
PMCR- 2015/01/01
CRDT- 2015/08/27 06:00
PHST- 2015/08/27 06:00 [entrez]
PHST- 2015/08/27 06:00 [pubmed]
PHST- 2015/08/27 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.1089/biores.2014.0034 [pii]
AID - 10.1089/biores.2014.0034 [doi]
PST - epublish
SO  - Biores Open Access. 2015 Jan 1;4(1):65-74. doi: 10.1089/biores.2014.0034. 
      eCollection 2015.