PMID- 26313782
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 34
DP  - 2015 Aug
TI  - Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical 
      Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations.
PG  - e1392
LID - 10.1097/MD.0000000000001392 [doi]
LID - e1392
AB  - The purpose of this study was to describe the patient characteristics, computed 
      tomography (CT) and F-fluorodeoxyglucose positron emission tomography (FDG PET) 
      findings, and clinical outcomes of primary pulmonary synovial sarcoma (PPSS), 
      together with their pathologic correlations. The medical records of 14 patients 
      with pathologically proven PPSS in a tertiary hospital from January 1997 to 
      December 2014 were retrospectively reviewed. The CT findings were evaluated. The 
      maximum standardized uptake value (maxSUV) of the tumors was obtained, and 
      clinical outcomes with respect to tumor recurrence and mortality were assessed by 
      Kaplan-Meier analysis. The median tumor size was 10.2 cm and the most common 
      anatomic location was the lung followed by the pleura/chest wall and mediastinum. 
      Most of the tumors appeared as single lesions and had circumscribed margins. All 
      the cases showed heterogeneous enhancement with necrotic or cystic portions, and 
      intratumoral vessels were frequently seen. Half of the tumors had intratumoral 
      calcifications, and tumor rupture, pleural/chest wall extension, and pleural 
      effusion occurred frequently. However, lymph node enlargement was rare. The 
      median maxSUV of the tumors was 4.35. Patient outcomes with respect to tumor 
      recurrence (n = 8, 57.1%) and death (n = 3, 21.4%) were poor despite their young 
      age, and the mean follow-up period was 28.5 months.In conclusion, PPSS usually 
      occurs in young adults, generally in the lung, presents as a large, circumscribed 
      mass, and tumor rupture or extension of the pleura/chest wall may occur. The 
      tumors often contain calcifications and vessels; they may exhibit triple 
      attenuation on enhanced CT images, and clinical outcomes are poor.
FAU - Kim, Gun Ha
AU  - Kim GH
AD  - From the Department of Radiology (GHK, MYK, HJK); Department of Pathology, 
      Research Institute of Radiology (JSS); and Department of Pulmonary and Critical 
      Care Medicine (C-MC), Division of Oncology, University of Ulsan College of 
      Medicine, Asan Medical Center, Seoul, South Korea.
FAU - Kim, Mi Young
AU  - Kim MY
FAU - Koo, Hyun Jung
AU  - Koo HJ
FAU - Song, Joon Seon
AU  - Song JS
FAU - Choi, Chang-Min
AU  - Choi CM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Biopsy/methods
MH  - Chemoradiotherapy/methods
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung/pathology/surgery
MH  - *Lung Neoplasms/epidemiology/pathology/therapy
MH  - Male
MH  - Neoplasm Recurrence, Local/diagnosis
MH  - Pneumonectomy/methods
MH  - Positron-Emission Tomography/methods
MH  - Radiopharmaceuticals
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - *Sarcoma, Synovial/epidemiology/pathology/therapy
MH  - Tertiary Care Centers/statistics & numerical data
MH  - Tomography, X-Ray Computed/methods
PMC - PMC4602937
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2015/08/28 06:00
MHDA- 2015/11/17 06:00
PMCR- 2015/08/28
CRDT- 2015/08/28 06:00
PHST- 2015/08/28 06:00 [entrez]
PHST- 2015/08/28 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
PHST- 2015/08/28 00:00 [pmc-release]
AID - 00005792-201508040-00019 [pii]
AID - 10.1097/MD.0000000000001392 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Aug;94(34):e1392. doi: 10.1097/MD.0000000000001392.