PMID- 26313783
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 34
DP  - 2015 Aug
TI  - Association of Change of Anthropometric Measurements With Incident Type 2 
      Diabetes Mellitus: A Pooled Analysis of the Prospective Population-Based CARLA 
      and SHIP Cohort Studies.
PG  - e1394
LID - 10.1097/MD.0000000000001394 [doi]
LID - e1394
AB  - Our objective was to investigate the association of change of anthropometric 
      measurements and the incidence of type 2 diabetes mellitus (T2DM) within a pooled 
      sample of 2 population-based cohorts.A final sample of 1324 women and 1278 men 
      aged 31 to 83 years from 2 prospective cohorts in Germany, the CARLA 
      (Cardiovascular Disease - Living and Ageing in Halle) and the SHIP study (Study 
      of Health in Pomerania), were pooled. The association of change of body weight 
      and waist circumference (WC) with incidence of T2DM was assessed by calculating 
      sex-specific hazard ratios (HRs). We investigated the absolute change of markers 
      of obesity as well as change relative to the baseline value and estimated crude 
      and adjusted HRs. Furthermore, we conducted the analyses stratified by obesity 
      status and age (<60 vs >/=60 years) at baseline.Associations were found for both 
      change of body weight and WC and incidence of T2DM in the crude and adjusted 
      analyses. In the stratified study sample, those participants with a body mass 
      index of <30 kg/m at baseline showed considerably lower HRs compared with obese 
      women and men for both weight and WC. In the age-stratified analysis, we still 
      found associations between change of weight and WC and incident T2DM with only 
      marginal differences between the age groups.Our study showed associations of 
      change of weight and WC as markers of obesity with incidence of T2DM. Keeping a 
      healthy and primarily stable weight should be the goal for preventing the 
      development of T2DM.
FAU - Hartwig, Saskia
AU  - Hartwig S
AD  - From the Institute of Medical Epidemiology, Biostatistics, and Informatics, 
      Martin-Luther-University Halle-Wittenberg, Halle (Saale) (SH, KHG, DM, DT, BH, 
      JH, AK); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 
      Heidelberg (KHG); Institute for Community Medicine, University Medicine 
      Greifswald, Greifswald (SS, TI, HV); and Institute of Epidemiology and Social 
      Medicine, University of Muenster, Muenster, Germany (GM).
FAU - Greiser, Karin Halina
AU  - Greiser KH
FAU - Medenwald, Daniel
AU  - Medenwald D
FAU - Tiller, Daniel
AU  - Tiller D
FAU - Herzog, Beatrice
AU  - Herzog B
FAU - Schipf, Sabine
AU  - Schipf S
FAU - Ittermann, Till
AU  - Ittermann T
FAU - Volzke, Henry
AU  - Volzke H
FAU - Muller, Grit
AU  - Muller G
FAU - Haerting, Johannes
AU  - Haerting J
FAU - Kluttig, Alexander
AU  - Kluttig A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anthropometry/methods
MH  - Body Mass Index
MH  - *Body Weight
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Obesity/complications/diagnosis
MH  - Population Surveillance
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Waist Circumference
PMC - PMC4602920
COIS- The authors report no conflicts of interest.
EDAT- 2015/08/28 06:00
MHDA- 2015/11/17 06:00
PMCR- 2015/08/28
CRDT- 2015/08/28 06:00
PHST- 2015/08/28 06:00 [entrez]
PHST- 2015/08/28 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
PHST- 2015/08/28 00:00 [pmc-release]
AID - 00005792-201508040-00020 [pii]
AID - 10.1097/MD.0000000000001394 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Aug;94(34):e1394. doi: 10.1097/MD.0000000000001394.