PMID- 26314579
OWN - NLM
STAT- MEDLINE
DCOM- 20170314
LR  - 20170314
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 126
IP  - 10
DP  - 2016 Oct
TI  - Impact of 5A/6A polymorphism of matrix metalloproteinase-3 on recurrent 
      atherosclerotic ischemic stroke in Chinese.
PG  - 936-41
LID - 10.3109/00207454.2015.1088013 [doi]
AB  - Little is known about the impact of the 5A/6A polymorphism of matrix 
      metalloproteinase-3 (MMP-3) on recurrence of atherosclerotic ischemic stroke in 
      Chinese. The aim of this study was to investigate the association of MMP-3 serum 
      level and 5A/6A genetic polymorphism with the recurrence of atherosclerotic 
      ischemic stroke in the Chinese Han population. We analyzed 106 large artery 
      atherosclerosis (LAA) recurrent ischemic stroke patients and 545 LAA first onset 
      ischemic stroke patients from January 2009 to June 2014. Serum MMP-3 
      concentrations were measured with an enzyme-linked immunosorbent assay. The 
      genotypes of MMP-3 promoter polymorphism (-1171 5A/6A) were determined using 
      polymerase chain reaction-restriction fragment length polymorphism. The 
      frequencies of MMP-3 5A/6A+5A/5A (32.08% vs. 21.47%, p = 0.02) genotype and 5A 
      (16.98% vs. 11.01%, p = 0.01) allele in the recurrent group was significantly 
      higher than those in the first onset group. After adjustment for vascular risk 
      factors, multivariate logistic regression analysis suggested that the MMP-3 
      5A/6A+5A/5A genotype was an independent risk factor for LAA recurrent ischemic 
      stroke (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.09-2.79, p = 
      0.021). No significant difference was observed for the MMP-3 serum concentrations 
      between the recurrent group and the first onset group (22.23 +/- 8.31 vs. 21.49 +/- 
      7.89 ng/ul, t = 0.88, p = 0.38). The MMP-3 (-1171 5A/6A) polymorphism may 
      contribute to LAA recurrent ischemic stroke susceptibility. Analysis of 5A/6A 
      polymorphism in MMP-3 may identify patients at higher risk for LAA ischemic 
      stroke recurrence, who may be selected for intensive preventive therapy.
FAU - Huang, Xiao-Ya
AU  - Huang XY
AD  - a Department of Neurology , Wenzhou Central Hospital & Dingli Clinical Institute 
      of Wenzhou Medical University , Wenzhou , China.
FAU - Han, Li-Ya
AU  - Han LY
AD  - a Department of Neurology , Wenzhou Central Hospital & Dingli Clinical Institute 
      of Wenzhou Medical University , Wenzhou , China.
FAU - Huang, Xiang-Dong
AU  - Huang XD
AD  - a Department of Neurology , Wenzhou Central Hospital & Dingli Clinical Institute 
      of Wenzhou Medical University , Wenzhou , China.
FAU - Guan, Chao-Hong
AU  - Guan CH
AD  - a Department of Neurology , Wenzhou Central Hospital & Dingli Clinical Institute 
      of Wenzhou Medical University , Wenzhou , China.
FAU - Mao, Xin-Lei
AU  - Mao XL
AD  - a Department of Neurology , Wenzhou Central Hospital & Dingli Clinical Institute 
      of Wenzhou Medical University , Wenzhou , China.
FAU - Ye, Zu-Sen
AU  - Ye ZS
AD  - b Department of Neurology , The First Affiliated Hospital of Wenzhou Medical 
      University , Wenzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20150922
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - *Atherosclerosis/blood/genetics
MH  - *Brain Ischemia/blood/genetics
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - *Matrix Metalloproteinase 3/blood/genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - *Stroke/blood/genetics
OTO - NOTNLM
OT  - atherosclerosis
OT  - ischemic stroke
OT  - matrix metalloproteinase-3
OT  - polymorphism
OT  - recurrence
OT  - stromelysin-1
EDAT- 2015/09/01 06:00
MHDA- 2017/03/16 06:00
CRDT- 2015/08/29 06:00
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2017/03/16 06:00 [medline]
AID - 10.3109/00207454.2015.1088013 [doi]
PST - ppublish
SO  - Int J Neurosci. 2016 Oct;126(10):936-41. doi: 10.3109/00207454.2015.1088013. Epub 
      2015 Sep 22.