PMID- 26314663
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20240109
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 160
IP  - 6
DP  - 2015 Dec
TI  - Morphology and Vascular Layers of the Choroid in Stargardt Disease Analyzed Using 
      Spectral-Domain Optical Coherence Tomography.
PG  - 1276-1284.e1
LID - S0002-9394(15)00531-0 [pii]
LID - 10.1016/j.ajo.2015.08.025 [doi]
AB  - PURPOSE: To analyze total thickness, morphology and individual vascular layers of 
      the choroid in eyes with Stargardt disease using spectral-domain optical 
      coherence tomography (SD OCT). DESIGN: Cross-sectional retrospective review. 
      METHODS: Twenty-eight patients with Stargardt disease (53 eyes) with a mean age 
      of 46 (15-79) years and 30 healthy subjects (30 eyes) with a mean age of 49 
      (22-79) years who underwent 1-line raster scanning with SD OCT were identified. 
      Diagnosis of Stargardt disease was based on ophthalmic history and complete 
      ophthalmic evaluation. The healthy subjects had best-corrected visual acuity of 
      20/20 or better with no chorioretinal pathology. Two independent raters assessed 
      the total thickness, morphology, and the individual vascular layers of the 
      choroid. RESULTS: The choroid was irregularly shaped in 26 of 41 eyes (64%) with 
      Stargardt disease when compared to 0 of 30 healthy eyes (0%). Mean subfoveal 
      total choroidal thickness and mean subfoveal large choroidal vessel layer 
      thickness were significantly reduced in eyes with Stargardt disease when compared 
      to healthy eyes (272.8 +/- 32.8 mum vs 225.4 +/- 69.9 mum; P = .03 and 219.5 +/- 30.6 
      vs169.2 +/- 70.1; P = .04, respectively). The maximal choroidal thickness was 
      subfoveal in 9 of 41 eyes (22%), focal choroidal thinning was observed in 21 of 
      41 eyes (51%), and attenuation of large choroidal vessel layer was observed in 8 
      of 41 eyes (20%) with Stargardt disease. There was no association of the 
      best-corrected visual acuity with any choroidal morphologic feature, except that 
      it was better by a mean of 0.61 +/- 0.21 in eyes that had preservation of large 
      choroidal vessel layer (33 of 41, 80%) when compared to those that had 
      attenuation of large choroidal vessel layer (P = .007). CONCLUSION: This study 
      shows alterations in the total thickness, morphology, and the individual vascular 
      layers of the choroid in eyes with Stargardt disease on SD OCT. These findings 
      may potentially contribute to the clinical staging and monitoring of Stargardt 
      disease.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Adhi, Mehreen
AU  - Adhi M
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
FAU - Read, Sarah P
AU  - Read SP
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
FAU - Ferrara, Daniela
AU  - Ferrara D
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
FAU - Weber, Marissa
AU  - Weber M
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
FAU - Duker, Jay S
AU  - Duker JS
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts.
FAU - Waheed, Nadia K
AU  - Waheed NK
AD  - New England Eye Center, Tufts Medical Center, Boston, Massachusetts. Electronic 
      address: nadiakwaheed@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150824
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
CIN - Am J Ophthalmol. 2015 Dec;160(6):1311-2. PMID: 26422831
CIN - Am J Ophthalmol. 2015 Dec;160(6):1311. PMID: 26572727
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Choroid/*blood supply
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macular Degeneration/*congenital/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retinal Vessels/*pathology
MH  - Retrospective Studies
MH  - Stargardt Disease
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2015/09/01 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/08/29 06:00
PHST- 2014/02/14 00:00 [received]
PHST- 2015/08/19 00:00 [revised]
PHST- 2015/08/19 00:00 [accepted]
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0002-9394(15)00531-0 [pii]
AID - 10.1016/j.ajo.2015.08.025 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 Dec;160(6):1276-1284.e1. doi: 10.1016/j.ajo.2015.08.025. 
      Epub 2015 Aug 24.