PMID- 26314929
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20151029
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 27
IP  - 11
DP  - 2015 Nov
TI  - Role of Oestrogen alpha Receptors in Sociosexual Behaviour in Female Rats Housed in a 
      Seminatural Environment.
PG  - 803-18
LID - 10.1111/jne.12321 [doi]
AB  - The present study investigated the role of oestrogen receptor (ER)alpha in the 
      ventromedial nucleus of the hypothalamus (VMN), the preoptic area (POA), the 
      medial amygdala (MePD) and the bed nucleus of stria terminalis (BNST) in 
      sociosexual behaviour in female rats. This was conducted in two sets of 
      experiments, with the VMN and POA investigated in the first set, and the MePD and 
      BNST in the second set. The VMN and POA received intense projections from the 
      MePD and BNST. We used a short hairpin RNA encoded within an adeno-associated 
      viral vector directed against the gene for ERalpha to reduce the number of ERalpha in the 
      VMN or POA (first set of experiments) or in the BNST or MePD (second set of 
      experiments) in female rats. The rats were housed in groups of four 
      ovariectomised females and three males in a seminatural environment for 8 days. 
      Compared with traditional test set-ups, the seminatural environment provides an 
      arena in which the rats can express their full behavioural repertoire, which 
      allowed us to investigate multiple aspects of social and sexual behaviour in 
      groups of rats. Behavioural observation was performed after oestrogen and 
      progesterone injections. A reduction of ERalpha expression in the VMN or POA 
      diminished the display of paracopulatory behaviours and lordosis responses 
      compared to controls, whereas the lordosis quotient remained unaffected. This 
      suggests that ERalpha in the VMN and POA play an important role in intrinsic sexual 
      motivation. The reduction in ERalpha did not affect the social behaviour of the 
      females, although the males sniffed and pursued the females with reduced ERalpha less 
      than the controls. This suggests that the ERalpha in the VMN and POA is involved in 
      the regulation of sexual attractiveness of females. The ERalpha in the MePD and BNST, 
      on the other hand, plays no role in sociosexual behaviour.
CI  - (c) 2015 British Society for Neuroendocrinology.
FAU - Snoeren, E M S
AU  - Snoeren EM
AD  - Department of Psychology, University of Tromso, Tromso, Norway.
FAU - Antonio-Cabrera, E
AU  - Antonio-Cabrera E
AD  - Department of Biology of Reproduction, Universidad Autonoma Metropolitana, Unidad 
      Iztapalapa, Mexico.
FAU - Spiteri, T
AU  - Spiteri T
AD  - Department of Psychology, University of Tromso, Tromso, Norway.
FAU - Musatov, S
AU  - Musatov S
AD  - Laboratory of Molecular Neurosurgery, Weil Medical College of Cornell University, 
      New York, NY, USA.
FAU - Ogawa, S
AU  - Ogawa S
AD  - Laboratory of Behavioral Neuroendocrinology, University of Tsukuba, Tsukuba, 
      Japan.
FAU - Pfaff, D W
AU  - Pfaff DW
AD  - Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, 
      NY, USA.
FAU - Agmo, A
AU  - Agmo A
AD  - Department of Psychology, University of Tromso, Tromso, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens)
RN  - 0 (RNA, Small Interfering)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Amygdala/physiology
MH  - Animals
MH  - Estrogen Receptor alpha/antagonists & inhibitors/*physiology
MH  - Estrogens/administration & dosage/pharmacology
MH  - Female
MH  - *Housing, Animal
MH  - Injections, Subcutaneous
MH  - Male
MH  - Preoptic Area/physiology
MH  - Progesterone/administration & dosage/pharmacology
MH  - RNA, Small Interfering/pharmacology
MH  - Rats
MH  - Septal Nuclei/physiology
MH  - Sexual Behavior, Animal/drug effects/*physiology
MH  - *Social Behavior
MH  - Ventromedial Hypothalamic Nucleus/physiology
OTO - NOTNLM
OT  - oestrogen receptor
OT  - rats
OT  - seminatural environment
OT  - sexual behaviour
OT  - social behaviour
EDAT- 2015/09/01 06:00
MHDA- 2016/08/19 06:00
CRDT- 2015/08/29 06:00
PHST- 2015/05/13 00:00 [received]
PHST- 2015/08/21 00:00 [revised]
PHST- 2015/08/21 00:00 [accepted]
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
AID - 10.1111/jne.12321 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2015 Nov;27(11):803-18. doi: 10.1111/jne.12321.