PMID- 26315843 OWN - NLM STAT- MEDLINE DCOM- 20161228 LR - 20220318 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 40 IP - 2 DP - 2016 Feb TI - Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity. PG - 275-80 LID - 10.1038/ijo.2015.174 [doi] AB - BACKGROUND/OBJECTIVES: Inflammation, oxidative stress and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes the levels of several adipokines, but little is known about the postsurgical changes among adolescents. SUBJECTS/METHODS: In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemo-attractant protein-1 (MCP-1), oxidized low-density lipoprotein cholesterol (oxLDL), adiponectin, leptin and resistin up to 12 months following elective laparoscopic Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity. RESULTS: In cohort 1, which consisted of 39 adolescents (mean age 16.5+/-1.6 years; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3+/-3.4 pg ml(-1) vs 12 months: 0.8+/-0.6 pg ml(-1), P<0.01), leptin (baseline: 178+/-224 ng ml(-1) vs 12 months: 41.4+/-31.9 ng ml(-1), P<0.001) and oxLDL (baseline: 41.6+/-11.6 U l(-1) vs 12 months: 35.5+/-11.1 U l(-1), P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4+/-2.4 mug ml(-1) vs 12 months: 13.5+/-8.9 mug ml(-1), P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5+/-1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7+/-0.9 pg ml(-1) vs 12 months: 0.4+/-0.9 pg ml(-1), P<0.05) and leptin (baseline: 92.9+/-31.3 ng ml(-1) vs 12 months: 37.3+/-33.4 ng ml(-1), P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1+/-2.9 mug ml(-1) vs 12 months: 15.4+/-8.0 mug ml(-1), P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8+/-16.7 U l(-1) vs 12 months: 32.7+/-11.9 U l(-1), P=0.03). CONCLUSIONS: Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease. FAU - Kelly, A S AU - Kelly AS AD - Department of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA. AD - Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Ryder, J R AU - Ryder JR AD - Department of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA. AD - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA. FAU - Marlatt, K L AU - Marlatt KL AD - Department of Pediatrics, University of Minnesota Medical School and University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA. AD - School of Kinesiology, University of Minnesota, Minneapolis, MN, USA. FAU - Rudser, K D AU - Rudser KD AD - Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA. FAU - Jenkins, T AU - Jenkins T AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Inge, T H AU - Inge TH AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. LA - eng GR - 8 UL1TR000077/TR/NCATS NIH HHS/United States GR - R03 DK068228/DK/NIDDK NIH HHS/United States GR - P30 DK078392/DK/NIDDK NIH HHS/United States GR - UL1 TR000114/TR/NCATS NIH HHS/United States GR - UL1 TR001425/TR/NCATS NIH HHS/United States GR - R03DK068228/DK/NIDDK NIH HHS/United States GR - 8 UL1 TR000077/TR/NCATS NIH HHS/United States GR - UL1TR000114/TR/NCATS NIH HHS/United States GR - UM1 DK072493/DK/NIDDK NIH HHS/United States GR - T32-DK083250/DK/NIDDK NIH HHS/United States GR - T32 DK083250/DK/NIDDK NIH HHS/United States GR - U01 DK072493/DK/NIDDK NIH HHS/United States GR - UL1 TR000077/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20150828 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 RN - 0 (ADIPOQ protein, human) RN - 0 (Adipokines) RN - 0 (Adiponectin) RN - 0 (Biomarkers) RN - 0 (IL6 protein, human) RN - 0 (Interleukin-6) RN - 0 (Lipoproteins, LDL) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Adipokines/*blood MH - Adiponectin/blood MH - Adolescent MH - Atherosclerosis/*etiology/physiopathology/prevention & control MH - Biomarkers/blood MH - Female MH - *Gastric Bypass MH - Humans MH - Inflammation/*etiology/physiopathology/prevention & control MH - Insulin Resistance MH - Interleukin-6/blood MH - Lipoproteins, LDL/blood MH - Male MH - Obesity, Morbid/complications/epidemiology/physiopathology/*surgery MH - Oxidative Stress MH - Pediatric Obesity/complications/epidemiology/physiopathology/*surgery MH - Postoperative Period MH - Time Factors MH - Tumor Necrosis Factor-alpha/blood MH - United States/epidemiology MH - *Weight Loss PMC - PMC5546415 MID - NIHMS888756 EDAT- 2015/09/01 06:00 MHDA- 2016/12/29 06:00 PMCR- 2017/08/07 CRDT- 2015/08/29 06:00 PHST- 2015/05/11 00:00 [received] PHST- 2015/07/14 00:00 [revised] PHST- 2015/08/03 00:00 [accepted] PHST- 2015/08/29 06:00 [entrez] PHST- 2015/09/01 06:00 [pubmed] PHST- 2016/12/29 06:00 [medline] PHST- 2017/08/07 00:00 [pmc-release] AID - ijo2015174 [pii] AID - 10.1038/ijo.2015.174 [doi] PST - ppublish SO - Int J Obes (Lond). 2016 Feb;40(2):275-80. doi: 10.1038/ijo.2015.174. Epub 2015 Aug 28.