PMID- 26316332
OWN - NLM
STAT- MEDLINE
DCOM- 20180228
LR  - 20220331
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 38 Suppl 1
DP  - 2016 Apr
TI  - Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of The MD 
      Anderson Cancer Center experience.
PG  - E1312-7
LID - 10.1002/hed.24219 [doi]
AB  - BACKGROUND: Mucoepidermoid carcinoma arises from major or minor salivary glands, 
      making up 10% of salivary gland tumors. Intraosseous mucoepidermoid carcinomas 
      are rare, and make up only 2% to 3% of all mucoepidermoid carcinomas. The 
      t(11;19) and its CRTC1-MAML2 fusion gene transcript have been identified in 
      mucoepidermoid carcinoma and are associated with a subset of mucoepidermoid 
      carcinomas. The extent to which the transcript influences disease features and 
      patient survival is unclear. METHODS: We conducted a retrospective analysis of 
      records for clinical features, surgical interventions, and prognoses. Reverse 
      transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ 
      hybridization (FISH) used to assess the t(11;19) fusion gene in intraosseous 
      mucoepidermoid carcinoma. RESULTS: Twenty-five patients with intraosseous 
      mucoepidermoid carcinoma treated between 1998 and 2013 were identified. The 
      t(11;19) fusion gene transcript CRTC1-MAML2 manifested in 9 intraosseous 
      mucoepidermoid carcinomas, whereas is was not detected in another 9 intraosseous 
      carcinomas. Although the incidence of this fusion in mucoepidermoid carcinoma 
      varies, it is generally accepted that more than 50% of this entity manifest the 
      CRTC1-MAML2. CONCLUSION: Intraosseous mucoepidermoid carcinoma diagnosis should 
      be based on clinical and pathologic manifestations and complete resection is the 
      first choice for patient treatment. The need for neck dissection and adjuvant 
      treatment are debatable. Radiotherapy may improve prognosis and may be 
      recommended in the postoperative period. Primary intraosseous mucoepidermoid 
      carcinoma can manifest the fusion transcript in a subset of tumors. (c) 2015 Wiley 
      Periodicals, Inc. Head Neck 38: E1312-E1317, 2016.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Bell, Diana
AU  - Bell D
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas.
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - Lewis, Carol
AU  - Lewis C
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - El-Naggar, Adel K
AU  - El-Naggar AK
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas.
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
FAU - Weber, Randal S
AU  - Weber RS
AD  - Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer 
      Center, Houston, Texas.
LA  - eng
PT  - Journal Article
DEP - 20150828
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (CRTC1 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MAML2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone Neoplasms/*pathology/surgery
MH  - Carcinoma, Mucoepidermoid/*pathology/surgery
MH  - Child
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Retrospective Studies
MH  - Salivary Gland Neoplasms/*pathology/surgery
MH  - Trans-Activators
MH  - Transcription Factors/genetics
OTO - NOTNLM
OT  - fusion transcript
OT  - histogenesis
OT  - intraosseous
OT  - mucoepidermoid carcinoma
OT  - translocation
EDAT- 2015/09/01 06:00
MHDA- 2018/03/01 06:00
CRDT- 2015/08/29 06:00
PHST- 2015/07/13 00:00 [accepted]
PHST- 2015/08/29 06:00 [entrez]
PHST- 2015/09/01 06:00 [pubmed]
PHST- 2018/03/01 06:00 [medline]
AID - 10.1002/hed.24219 [doi]
PST - ppublish
SO  - Head Neck. 2016 Apr;38 Suppl 1:E1312-7. doi: 10.1002/hed.24219. Epub 2015 Aug 28.